| 100% | GLENN | 5 | First U.S. astronaut to circle the earth |
| 56% | STLOUIS | 7 | First U.S. city to host the Olympics |
| 56% | GLENN | 5 | John —, first American astronaut to orbit the earth |
| 55% | STLOUIS | 7 | First U.S. city to host the Olympic Games |
| 55% | STL | 3 | First U.S. city to host the Olympics (Abbr.) |
| 55% | STL | 3 | First U.S. city to host the Olympic Games |
| 54% | TYLER | 5 | First U.S. vice president to ascend to the presidency |
| 53% | NYRANGERS | 9 | First U.S. team to win the N.H.L. Stanley Cup (1928) |
| 48% | STLOUIS | 7 | First US city to host the Olympic Games |
| 48% | DEL | 3 | First state to ratify the U.S. Constitution: Abbr. |
| 48% | SHIRLEYCHISHOLM | 15 | First Black woman elected to the U.S. Congress |
| 47% | OUR | 3 | Belonging to us, also the first word in the Lord's prayer |
| 47% | RANGER | 6 | __ 4; first US spacecraft to reach the Moon |
| 47% | GAGARIN | 7 | First person to orbit the Earth |
| 47% | JOHNGLENN | 9 | First American to orbit the Earth |
| 47% | ADAM | 4 | First man to walk the Earth? |
| 47% | GLENN | 5 | First American to orbit the Earth |
| 47% | GGLLEENNNN | 10 | First American to orbit the earth |
| 47% | THEM | 4 | The first to mix? Not us |
| 47% | THEM | 4 | The first to sew? Not us |
| 47% | THEM | 4 | The first to join? Not us |
| 47% | NEIL | 4 | First name in NASA's prestigious list of astronauts who have been to the moon |
| 46% | ASHE | 4 | First Black man to win the U.S. Open |
| 46% | THEM | 4 | The first to turn up? Not us |
| 46% | DEL | 3 | First state admitted to the US: Abbr. |
| 46% | ODDITY | 6 | David Bowie's hit "Space ___" that introduced us to the fictional astronaut "Major Tom" |
| 45% | ENOS | 4 | First chimpanzee to orbit the Earth in 1961 |
| 45% | BOBBEAMON | 9 | US long-jumper, the first to reach 29ft |
| 45% | WARRENGHARDING | 14 | U.S. president who, in 1922, became the first president to have his voice transmitted on the radio (3 wds.) |
| 45% | NEILARMSTRONG | 13 | First astronaut to walk on the moon: 2 wds. |