| 100% | YALE | 4 | First U.S. university to award a Ph.D. |
| 62% | YALE | 4 | University that awarded the first Ph.D. in the U.S. |
| 53% | OBERLIN | 7 | First U.S. college to award degrees to women |
| 53% | PENNY | 5 | First U.S. coin to feature a president |
| 51% | DETROIT | 7 | First U.S. city to pave a road for cars |
| 51% | HST | 3 | First U.S. pres. to travel in a submarine |
| 51% | PENNY | 5 | First U.S. coin to feature a real person’s image |
| 48% | YALE | 4 | College that awarded the first Ph.D. in the U.S. |
| 46% | YALE | 4 | University that awarded the first Ph.D. in the United States |
| 46% | ELMO | 4 | Saint ___ Brady, first African American in the US to obtain a Ph.D. degree in chemistry (University of Illinois, 1916) |
| 45% | UNIVAC | 6 | First computer to predict a U.S. election outcome |
| 43% | ELVIS | 5 | First rock star to appear on a U.S. stamp |
| 42% | VERMONT | 7 | First U.S. state to abolish slavery |
| 42% | NIXON | 5 | First U.S. President to visit China |
| 42% | DELAWARE | 8 | First Indian tribe to sign a treaty with the U.S. government |
| 41% | TEXAS | 5 | U.S.S. ___, first battleship to become a state shrine |
| 41% | STLOUIS | 7 | First U.S. city to host the Olympics |
| 41% | GLENN | 5 | First U.S. astronaut to circle the earth |
| 41% | IKEA | 4 | First company to feature a gay couple in a mainstream U.S. TV ad (1994) |
| 41% | BURR | 4 | First U.S. vice president not to become president |
| 41% | STLOUIS | 7 | First U.S. city to host the Olympic Games |
| 41% | STL | 3 | First U.S. city to host the Olympics (Abbr.) |
| 41% | STL | 3 | First U.S. city to host the Olympic Games |
| 40% | TYLER | 5 | First U.S. vice president to ascend to the presidency |
| 40% | MEIR | 4 | First U.S. citizen to become Israel’s P.M. |
| 40% | HAMPSHIRE | 9 | First U.S. college to divest from apartheid South Africa |
| 40% | APPLE | 5 | First U.S. company to be valued at $1 trillion |
| 40% | SERIAL | 6 | First podcast to win a Peabody Award (2015) |
| 40% | DEVILDOG | 8 | U.S. marine, to a marine |
| 40% | SHAKINA | 7 | First trans person to star in a US network sitcom: Nayfack of "Connecting" |