| 100% | JACKSON | 7 | First US President to be the target of an assassination attempt (which failed), on January 30, 1835 |
| 38% | ABE | 3 | Nickname of the first US president to be assassinated |
| 37% | ANDREWJACKSON | 13 | The 7th US president and hero of the battle of New Orleans was 1st to be targeted for assassination |
| 34% | USN | 3 | JFK was the first president to have served in this branch of the US Armed Forces |
| 33% | JAMESMADISON | 12 | U.S. president who was the first to have served in the House of Representatives, the first to have an inaugural ball, and the first to wear long pants instead of knee breeches (2 wds.) |
| 31% | REAGAN | 6 | First U.S. president with a star on the Hollywood Walk of Fame |
| 30% | UEL | 3 | First name of the NW Missouri State U. president (1921-45) after which Maryville's Lamkin Activity Center is named |
| 30% | FDR | 3 | Initials of the only US president to be elected four times |
| 30% | DOG | 3 | President Trump is the first president in over 100 years not to have one of these |
| 30% | NAOMAMPBELL | 11 | *Woman who was the first Black model to appear on the cover of Time |
| 29% | HARRYTRUMAN | 11 | President whose State of the Union Address was the first to be broadcast live on television (2 wds.) |
| 29% | SAHLE | 5 | ___-Work Zewde, Ethiopian politician who is the first woman to serve as the President of Ethiopia |
| 29% | DEVI | 4 | Bidya ___ Bhandari, Nepalese politician who is the first woman to serve as the President of Nepal |
| 29% | NEHRU | 5 | His sister, Vijaya Lakshmi Pandit, was the first female president of the U.N. General Assembly |
| 29% | ELAYNE | 6 | Boosler who was the first woman to have an hour-long comedy special on cable TV |
| 29% | RETTON | 6 | Gymnast Mary Lou who was the first woman to appear on the front of a Wheaties box |
| 29% | JOHNSON | 7 | He was US president for the first 20 days of 1969 |
| 29% | LYNDONJOHNSON | 13 | President whose State of the Union Address was the first to be broadcast live on prime-time television (2 wds.) |
| 28% | WARRENHARDING | 13 | U.S. president who was the first to be elected on his birthday, the first born after the Civil War, and the first elected after women gained the right to vote (2 wds.) |
| 28% | IGGYAZALEA | 10 | "Fancy" singer who is one of only two music acts to have their first two hit singles rank #1 and #2 simultaneously on the U.S. "Billboard" Hot 100 chart (2 wds.) |
| 28% | GERALDFORD | 10 | 38th US president (1974-1977) who was on the varsity football team at the University of Michigan: 2 wds. |
| 28% | BAD | 3 | "___ was the blood of the song in the cab / On your first trip to L.A." |
| 28% | GODSAVETHEQUEEN | 15 | "Pray we can hold on to the smaller one, which is more comfortable than the king" |
| 28% | TRIP | 4 | "Bad was the blood of the song in the cab on your first ___ to L.A." ("Invisible String" lyric) |
| 27% | WOODROWWILSON | 13 | The 28th US President and leader of the progressive movement was the first attend a world series |
| 27% | GODSAVETHEQUEEN | 15 | "Pray we can hold on to the smaller one, which is more comfortable than the king" |
| 27% | CROP | 4 | Expanded part of the oesophagus in birds in which food is stored before passing on to the gizzard |
| 27% | NINE | 4 | Musical whose numerical title adds one-half to that of the Fellini film on which it is based |
| 27% | HAMMURABI | 9 | Babylonian King, said to be the first set of laws |
| 27% | TELESCOPE | 9 | Notable invention from the 17th century, that is an assembly of lenses and allows us to look into space |