| 100% | BESSIECOLEMAN | 13 | First woman of African-American and Native American descent to earn an international pilot's license (2 wds.) |
| 46% | HARRIETQUIMBY | 13 | First woman to earn a pilot's license in the United States and the first woman to fly across the English Channel (2 wds.) |
| 41% | STEVIENICKS | 11 | American singer and songwriter who became the first woman to be inducted twice into the Rock and Roll Hall of Fame: 2 wds. |
| 40% | RASHIDATLAIB | 12 | First woman of Palestinian descent to serve in Congress and the first Muslim woman to serve in the Michigan legislature (2 wds.) |
| 39% | SUSAN | 5 | ___ La Flesche Picotte, doctor and reformer who was the first Native American woman to earn a medical degree |
| 38% | TONIMORRISON | 12 | "Beloved" author who died August 5, and who was the first African-American woman to win a Nobel Prize: 2 wds. |
| 38% | VENUSWILLIAMS | 13 | First African-American woman to hold the world #1 ranking in tennis's Open era: 2 wds. |
| 38% | MICHELLEOBAMA | 13 | First African-American woman to serve as First Lady of the United States (2 wds.) |
| 36% | VENUSWILLIAMS | 13 | First African-American tennis player to be ranked #1 in women's singles during the Open Era: 2 wds. |
| 36% | MARIATALLCHIEF | 14 | Native American dancer in the National Women's Hall of Fame: 2 wds. |
| 35% | ETHELWATERS | 11 | Harlem Renaissance singer and actress who was the first African American to star in her own TV show: 2 wds. |
| 35% | MARTHAGRAHAM | 12 | American dancer who was the first dancer to perform at the White House and to receive the Presidential Medal of Freedom: 2 wds. |
| 35% | MELISSAARNOT | 12 | Mountaineer who climbed Mount Everest six times and became the first woman to survive a descent without supplemental oxygen: 2 wds. |
| 35% | BUZZALDRIN | 10 | Lunar module pilot on the Apollo 11 mission and one of the first two humans to land on the moon: 2 wds. |
| 35% | EDMONIALEWIS | 12 | African-American and Native American sculptor who is honored on a 2022 U.S. postage stamp (2 wds.) |
| 35% | JANETJACKSON | 12 | "Rhythm Nation" R&B singer who received the 1990 MTV Video Vanguard Award, the first African American woman to do so: 2 wds. |
| 34% | GRETATHUNBERG | 13 | First Swedish woman and first person born in the 21st century to be named "Time" magazine's Person of the Year (2 wds.) |
| 34% | SALLYRIDE | 9 | First American woman to travel into space (1983): 2 wds. |
| 34% | ALTHEAGIBSON | 12 | First African-American woman to win the Women's Singles championship at Wimbledon (2 wds.) |
| 34% | TIGERWOODS | 10 | First African-American to win golf's Masters Tournament: 2 wds. |
| 34% | DANICAPATRICK | 13 | First woman to win an IndyCar event: 2 wds. |
| 34% | STEPHENSTILLS | 13 | American singer and songwriter who is the first artist to be inducted twice on the same night into the Rock and Roll Hall of Fame: 2 wds. |
| 34% | LORNASIMPSON | 12 | "Projects 23" photographer who was the first African-American woman to have a solo exhibition at the Museum of Modern Art (2 wds.) |
| 34% | SAMUELGOMPERS | 13 | Founder and first president of the American Federation of Labor: 2 wds. |
| 34% | HELENHAYES | 10 | First (and oldest) woman to achieve an EGOT (2 wds.) |
| 33% | LIZCAMBAGE | 10 | First woman to dunk in an Olympic basketball game: 2 wds. |
| 33% | HEMIN | 5 | To fold and sew an edge of an outfit: 2 wds. |
| 33% | JANETRENO | 9 | First woman to serve as attorney general of the US: 2 wds. |
| 33% | STANDBACK | 9 | 1983 top 10 hit for Stevie Nicks, the first woman to be inducted twice (in 1998 and 2019) into the Rock and Roll Hall of Fame: 2 wds. |
| 33% | TONIMORRISON | 12 | First African-American woman to win the Nobel Prize for Literature (2 wds.) |