| 100% | RASHIDATLAIB | 12 | First woman of Palestinian descent to serve in Congress and the first Muslim woman to serve in the Michigan legislature (2 wds.) |
| 40% | SARAHPALIN | 10 | In 2006, she became the first woman to be elected governor of Alaska: 2 wds. |
| 40% | SUSANAMARTINEZ | 14 | In 2010, she became the first woman to be elected governor of New Mexico: 2 wds. |
| 40% | NIKKIHALEY | 10 | In 2010, she became the first woman to be elected governor of South Carolina: 2 wds. |
| 40% | JANETRENO | 9 | First woman to serve as attorney general of the US: 2 wds. |
| 39% | GRETATHUNBERG | 13 | First Swedish woman and first person born in the 21st century to be named "Time" magazine's Person of the Year (2 wds.) |
| 38% | ALYSSANAKKEN | 12 | First woman to coach on the field of a Major League Baseball game, for the San Francisco Giants in 2020: 2 wds. |
| 38% | MELISSAARNOT | 12 | Mountaineer who climbed Mount Everest six times and became the first woman to survive a descent without supplemental oxygen: 2 wds. |
| 38% | MICHELLEOBAMA | 13 | First African-American woman to serve as First Lady of the United States (2 wds.) |
| 37% | STANDBACK | 9 | 1983 top 10 hit for Stevie Nicks, the first woman to be inducted twice (in 1998 and 2019) into the Rock and Roll Hall of Fame: 2 wds. |
| 37% | EDITHWHARTON | 12 | 13-Across and 25-Across writer who was the first woman to win a Pulitzer Prize in Literature, for her 1920 novel "The Age of Innocence" (2 wds.) |
| 37% | KATIESOWERS | 11 | First woman in the NFL to coach in a Super Bowl, for the San Francisco 49ers in 2020: 2 wds. |
| 37% | BESSIECOLEMAN | 13 | First woman of African-American and Native American descent to earn an international pilot's license (2 wds.) |
| 37% | JANEADDAMS | 10 | First American woman to be awarded the Nobel Peace Prize, in 1931: 2 wds. |
| 36% | STEVIENICKS | 11 | American singer and songwriter who became the first woman to be inducted twice into the Rock and Roll Hall of Fame: 2 wds. |
| 36% | BUZZALDRIN | 10 | Lunar module pilot on the Apollo 11 mission and one of the first two humans to land on the moon: 2 wds. |
| 36% | BECKYHAMMON | 11 | First woman to act as head coach in an NBA game, for the San Antonio Spurs in 2020: 2 wds. |
| 36% | HANKAARON | 9 | Braves and Brewers star who gained first-ballot induction to the Baseball Hall of Fame in 1982 with 97.8% of the vote: 2 wds. |
| 35% | FRANCESARNOLD | 13 | First American woman to win the Nobel Prize in Chemistry, in 2018: 2 wds. |
| 35% | JAMESMADISON | 12 | U.S. president who was the first to have served in the House of Representatives, the first to have an inaugural ball, and the first to wear long pants instead of knee breeches (2 wds.) |
| 35% | JACKIESTILES | 12 | 2016 Women's Basketball Hall of Fame inductee who was the first Division I player to score over 1,000 points in a season: 2 wds. |
| 35% | EVELYNASHFORD | 13 | The first track and field athlete to run 100 meters under 11 seconds in an Olympic Games and who has won a total of 5 Olympic medals: 2 wds. |
| 35% | DEBBIEHARRY | 11 | Lead singer of Blondie who received the first Billboard Women in Music Icon Award, in 2008: 2 wds. |
| 34% | OMAR | 4 | Ilhan ___, one of the first two Muslim women elected to Congress |
| 34% | ETHELWATERS | 11 | Harlem Renaissance singer and actress who was the first African American to star in her own TV show: 2 wds. |
| 34% | SHERYL | 6 | I wrote "Lean In" and became the first woman to join Facebook's board of directors |
| 34% | SOLANGEKNOWLES | 14 | 12-Across and 28-Across singer who was the first recipient of the "Billboard" Women in Music Impact Award (2 wds.) |
| 34% | EDITH | 5 | ___ Wharton, "The Age of Innocence" novelist and the first woman to win the Pulitzer Prize in Literature |
| 34% | HARRIETQUIMBY | 13 | First woman to earn a pilot's license in the United States and the first woman to fly across the English Channel (2 wds.) |
| 34% | AOC | 3 | Youngest woman to serve in the State Congress, familiarly |