| 100% | MIAMI | 5 | Florida setting of a 2002-2012 "CSI" spin-off |
| 44% | JUMPSTARTING | 12 | Setting off with a boost of energy |
| 42% | MIAMI | 5 | City where a "CSI" spin-off was set |
| 41% | HAZYSTACKS | 10 | Result of setting off a smoke bomb in a library? |
| 40% | GOMERPYLEUSMC | 13 | Sitcom set at a military base that was a spin-off of "The Andy Griffith Show" (3 wds.) |
| 40% | MEDITERRANEAN | 13 | Bravo spin-off of 15-Across since 2016, set off the coast of Europe |
| 40% | ARSON | 5 | Setting of a fire maliciously |
| 40% | BABEL | 5 | Setting of a biblical tower |
| 40% | YALTA | 5 | Setting of a 1945 conference |
| 40% | ROAD | 4 | Setting of a fork, perhaps |
| 40% | FAMILYMATTERS | 13 | Sitcom set in Chicago that was a spin-off of "Perfect Strangers" (2 wds.) |
| 39% | COPA | 4 | Setting of a Barry Manilow hit |
| 39% | POKERFLAT | 9 | Setting of a Bret Harte tale |
| 39% | SAIGON | 6 | Setting of a 1991 Broadway musical |
| 39% | SEATTLE | 7 | Setting of a Ryan-Hanks film |
| 39% | AMITYVILLE | 10 | Setting of a 1979 horror flick |
| 39% | CSIMIAMI | 8 | Forensic TV spin-off set in Florida |
| 39% | MIAMI | 5 | Florida setting of many Carl Hiaasen novels |
| 39% | MASTERPLANET | 12 | Setting of a sci-fi slave story? |
| 39% | CAIRO | 5 | Setting of a trilogy by Naguib Mahfouz |
| 39% | IWOJIMA | 7 | Setting of a famous flag-raising photo |
| 39% | TOYLAND | 7 | Setting of a 1903 Victor Herbert operetta |
| 38% | DOMINO | 6 | ___ Effect, cumulative effect where one event sets off a chain reaction of related events |
| 38% | DOWNUNDER | 9 | Bravo/Peacock spin-off of 15-Across since 2022, set off the coast of Australia: 2 wds. |
| 38% | COPA | 4 | Setting of a top 10 Barry Manilow hit |
| 38% | RENO | 4 | Setting of a 2000s Comedy Central police show |
| 38% | IWO | 3 | Setting of a 1945 Pulitzer-winning photo, briefly |
| 38% | YALTA | 5 | Crimean setting of a 1945 conference |
| 37% | OTRANTO | 7 | Italian city, setting of a Walpole novel |
| 37% | MILA | 4 | ___ 18 (title setting of a 1961 novel) |