| 100% | JAYLENO | 7 | Former "Tonight Show" host who used to work at McDonald's: 2 wds. |
| 60% | EVALONGORIA | 11 | "Telenovela" actress who used to work at Wendy's: 2 wds. |
| 55% | BARACKOBAMA | 11 | US president who used to work at Baskin-Robbins: 2 wds. |
| 53% | JOHNOLIVER | 10 | Former "Daily Show" correspondent who hosts HBO's "Last Week Tonight": 2 wds. |
| 50% | CALVINHARRIS | 12 | DJ and producer with hits like "Summer" and "Feel So Close," who used to work at a supermarket, before becoming a musician: 2 wds. |
| 50% | RICKILAKE | 9 | Former talk show host who premiered her documentary "Weed the People" at the SXSW festival in Austin: 2 wds. |
| 48% | JAYLENO | 7 | Former "Tonight Show" host who was awarded the Mark Twain Prize in 2014: 2 wds. |
| 47% | MICHELLEWOLF | 12 | Former Netflix variety show host who performed at the 2018 White House Correspondents' Dinner: 2 wds. |
| 46% | CONANOBRIEN | 11 | Late-night host who moved to TBS after leaving "The Tonight Show": 2 wds. |
| 46% | JAY | 3 | Leno who used to host "The Tonight Show" |
| 46% | LENO | 4 | Comedian Jay who used to host The Tonight Show |
| 43% | JIMMYKIMMEL | 11 | ABC talk show host who performed at the 2012 White House Correspondents' Dinner: 2 wds. |
| 43% | CONANOBRIEN | 11 | TBS talk show host who performed at the 2013 White House Correspondents' Dinner: 2 wds. |
| 43% | JIMMYFALLON | 11 | "The Tonight Show" host who introduced these raps on "Late Night": 2 wds. |
| 43% | JIMMYFALLON | 11 | "The Tonight Show" host who just published his second picture book, "Everything Is MAMA": 2 wds. |
| 42% | ROBRIGGLE | 9 | Former "Daily Show" correspondent who hosted the ESPY Awards in 2012: 2 wds. |
| 42% | HASANMINHAJ | 11 | Former "Daily Show" correspondent who hosts "Patriot Act" on Netflix: 2 wds. |
| 42% | SAMANTHABEE | 11 | Former "Daily Show" correspondent who hosts "Full Frontal" on TBS: 2 wds. |
| 42% | JONSTEWART | 10 | Former "Daily Show" host who won a Spoken Word Grammy for "Earth (The Audiobook)": 2 wds. |
| 42% | DAVIDLETTERMAN | 14 | Former "Late Show" host who presented Conan O'Brien with the 2025 Twain Prize: 2 wds. |
| 41% | JIMMYKIMMEL | 11 | Late-night talk show host who hosts the prime-time game show "Who Wants to Be a Millionaire": 2 wds. |
| 40% | JOHNNYCARSON | 12 | American talk show host and comedian who hosted "The Tonight Show" for three straight decades: 2 wds. |
| 40% | THEVOICE | 8 | American reality show hosted by Carson Daly, which works in a format similar to 21-Across: 2 wds. |
| 39% | OPRAHWINFREY | 12 | TV talk show host who received the NAACP's Spingarn Medal in 2000: 2 wds. |
| 39% | JAYLENO | 7 | Former "Tonight Show" host whose first name sounds like a letter of the alphabet: 2 wds. |
| 39% | JAMESCORDEN | 11 | English late night show host who was the co-creator of BBC's Gavin & Stacey: 2 wds. |
| 38% | CHARLIEROSE | 11 | PBS interview show host who's also a CBS journalist: 2 wds. |
| 38% | JAMESCORDEN | 11 | Former "The Late Late Show" host who plays No Name in "Smurfs": 2 wds. |
| 38% | LATENIGHT | 9 | After-hours NBC talk show hosted by Jimmy Fallon (who it's said will replace Jay Leno on "The Tonight Show"): 2 wds. |
| 38% | JIMMYKIMMEL | 11 | American late night show host who was the co-host of Comedy Central's "The Man Show": 2 wds. |