| 100% | LAURABUSH | 9 | Former First Lady whose charitable foundation supports school libraries: 2 wds. |
| 38% | ELTONJOHN | 9 | "Your Song" singer whose charitable foundation helps people with AIDS: 2 wds. |
| 38% | HILLARYCLINTON | 14 | Former First Lady who has been on the Time 100 list 10 times: 2 wds. |
| 38% | ALEXSMITH | 9 | Chiefs quarterback whose charitable foundation sponsors adult transition programs for foster teens: 2 wds. |
| 38% | MATTDAMON | 9 | "The Martian" actor whose charitable foundation provides drinking water in developing regions: 2 wds. |
| 37% | LAURABUSH | 9 | Former First Lady with a November birthday (2 wds.) |
| 37% | MICHELLEOBAMA | 13 | Former First Lady with a January birthday (2 wds.) |
| 35% | LAURABUSH | 9 | Former first lady who wrote the memoir "Spoken from the Heart" (2 wds.) |
| 35% | MICHELLEOBAMA | 13 | Former First Lady and "Becoming" author who was on the cover of the Winter 2021/22 issue of Vogue Knitting: 2 wds. |
| 35% | JACKIEKENNEDY | 13 | Former First Lady of the United States who was born in July (2 wds.) |
| 35% | MICHELLEOBAMA | 13 | First Lady known for her support of military families and healthy eating: 2 wds. |
| 34% | MICHELLEOBAMA | 13 | Former first lady who wrote the memoirs "Becoming" and "The Light We Carry" (2 wds.) |
| 34% | BETTYFORD | 9 | Former first lady who co-wrote the memoir "The Times of My Life" (2 wds.) |
| 32% | ADAMS | 5 | Abigail ___, former first lady whose ghost is said to haunt the White House |
| 32% | LAURABUSH | 9 | First Lady before Michelle Obama: 2 wds. |
| 32% | LADYBIRD | 8 | First Lady Johnson's nickname: 2 wds. |
| 31% | FULLYEARS | 9 | "Recollections of ___," 1914 book written by the former first lady of the US, Helen Herron Taft: 2 wds. |
| 30% | MALIAOBAMA | 10 | Former First Daughter born on the Fourth of July, 1998: 2 wds. |
| 30% | ROSALYNNCARTER | 14 | First Lady who wrote the 1984 memoir "First Lady From Plains": 2 wds. |
| 30% | LAURABUSH | 9 | First Lady who wrote the 2010 memoir "Spoken From the Heart": 2 wds. |
| 30% | MICHELLEOBAMA | 13 | First Lady of the United States (2009-2017) who wrote "Becoming": 2 wds. |
| 29% | BETTYFORD | 9 | First Lady who wrote the 1978 memoir "The Times of My Life": 2 wds. |
| 29% | BARBARABUSH | 11 | First Lady of the United States (1989-1993) who wrote "Millie's Book": 2 wds. |
| 29% | LAURALINNEY | 11 | "Ozark" actress who plays former First Lady Abigail Adams in "John Adams" (2 wds.) |
| 28% | NANCYREAGAN | 11 | First Lady of the United States (1981-1989) who wrote "To Love a Child": 2 wds. |
| 28% | KATIEHOLMES | 11 | She played First Lady Jacqueline Kennedy in Reelz' 2011 miniseries "The Kennedys": 2 wds. |
| 28% | ELLAFITZGERALD | 14 | "The First Lady of Song," who would have turned 100 next Tuesday: 2 wds. |
| 28% | BESS | 4 | Former First Lady |
| 28% | MAMIE | 5 | Former first lady |
| 28% | MICHELLEOBAMA | 13 | First Lady who sang "This Is for My Girls" with Missy Elliott in "Carpool Karaoke": 2 wds. |