| 100% | TIMRUSSERT | 10 | Former NBC News Washington bureau chief who hosted 42-Across from 1991 to 2008 (2 wds.) |
| 66% | DAVIDGREGORY | 12 | Former NBC News White House correspondent who hosted 42-Across from 2008 to 2014 (2 wds.) |
| 34% | JONATHANLEMIRE | 14 | "Politico" White House bureau chief who has hosted 44-Across since 2020 (2 wds.) |
| 34% | AHMADRASHAD | 11 | Former Vikings wide receiver who hosted 18-Across from 1990-2004: 2 wds. |
| 31% | MARKJACKSON | 11 | Former NBA guard who coached the Warriors from 2011 to 2014: 2 wds. |
| 30% | WILLIEGEIST | 11 | "Sunday Today" anchor who hosted 44-Across from 2009 to 2012 (2 wds.) |
| 30% | ZUBINMEHTA | 10 | Indian-born conductor who led the New York Philharmonic from 1978 to 1991: 2 wds. |
| 30% | EDSULLIVAN | 10 | Sports/entertainment reporter who hosted a musical variety show from 1948 to 1971: 2 wds. |
| 30% | CAROLBURNETT | 12 | Comedic actress/singer who hosted her own variety show from 1967 to 1978: 2 wds. |
| 29% | TIMOTHYBRADLEY | 14 | Former boxer with five world titles who followed a vegan diet for his fights from 2008 to 2015: 2 wds. |
| 29% | AHMADRASHAD | 11 | Former NFL wide receiver who hosted the game show "Tug of Words" from 2021-2022: 2 wds. |
| 28% | ROGERFEDERER | 12 | Swiss tennis player who won the US Open from 2004 to 2008: 2 wds. |
| 28% | LILLYSINGH | 10 | Comedian/YouTuber who hosted NBC's "A Little Late": 2 wds. |
| 28% | MIGUELINDURAIN | 14 | Spanish cyclist who won five Tour de France titles from 1991 to 1995: 2 wds. |
| 27% | JOELIEBERMAN | 12 | Former Connecticut senator who changed his party affiliation from Democrat to Independent: 2 wds. |
| 27% | JOANRIVERS | 10 | Late comedian who hosted "The Late Show" on Fox from 1986-1987: 2 wds. |
| 27% | JIMTHOME | 8 | Infielder who struck out 2,548 times from 1991 to 2012, second on the all-time list: 2 wds. |
| 27% | SPACEGHOST | 10 | Animated hero who hosted a "Coast to Coast" talk show on 45-Across (2 wds.) |
| 26% | ELIZABETHDOLE | 13 | Former North Carolina senator who changed her party affiliation from Democrat to Republican: 2 wds. |
| 26% | BORISBECKER | 11 | German tennis star who coached 30-Across from 2013 to 2016: 2 wds. |
| 26% | MELISSARIVERS | 13 | Daughter of Joan who cohosted 54-Across from 2015 to 2017: 2 wds. |
| 26% | PANAM | 5 | US airline from 1927 to 1991: 2 wds. |
| 26% | SAMANTHABEE | 11 | Comedian who hosts 36-Across: 2 wds. |
| 25% | ERINBURNETT | 11 | CNN journalist who hosts the nightly news program "OutFront" (2 wds.) |
| 25% | TOMBROKAW | 9 | "NBC Nightly News" anchor from 1982 to 2004 (2 wds.) |
| 25% | DAVIDGREGORY | 12 | CNN political analyst who was the moderator of 14-Across from 2008 to 2014: 2 wds. |
| 25% | LAURENHOLLY | 11 | Actress who played NCIS Director Jenny Shepard on "NCIS" from 2005 to 2008 (2 wds.) |
| 24% | JAYLENO | 7 | Former "Tonight Show" host who used to work at McDonald's: 2 wds. |
| 24% | CITYSLICKERS | 12 | Comedy film starring 42-Across as a New Yorker who goes on a cattle drive with his friends (2 wds.) |
| 24% | PANAM | 5 | U.S. airline from 1927 to 1991, casually: 2 wds. |