| 100% | ANNLEE | 6 | Founder of the first U.S. Shaker colony |
| 74% | ANNLEE | 6 | Founder of the first Shaker colony in America |
| 66% | ANNLEE | 6 | Founder of the Shakers, in the U.S. |
| 56% | IKE | 3 | Nickname of the first U.S. president born in 7-Down |
| 56% | ANNAJARVIS | 10 | Founder of the Mother's Day holiday in the U.S. who held the first official observance in honor of mothers in 1908: 2 wds. |
| 53% | KNOX | 4 | Kentucky fort named after the first U.S. Secretary of War |
| 52% | OSAKA | 5 | Home of the first Universal Studios outside the U.S. |
| 52% | ANNLEE | 6 | Founder of the Shakers |
| 52% | LEE | 3 | Founder of the Shakers |
| 51% | ANNLEE | 6 | Founder of the American Shakers |
| 51% | TCCHEN | 6 | Scorer of the first double eagle in U.S. Open history, 1985 |
| 51% | OSLO | 4 | Home of the first U.N. secretary general |
| 50% | REAGAN | 6 | First U.S. president with a star on the Hollywood Walk of Fame |
| 50% | ABE | 3 | Nickname of the first US president to be assassinated |
| 50% | ANNLEE | 6 | Founder of the Shakers in America [1736] |
| 50% | ANNLEE | 6 | Historic founder of the Shakers |
| 50% | GUS | 3 | Skier Kenworthy who was one of the first out gay U.S. Winter Olympians |
| 49% | RCA | 3 | Developer of the U.S.'s first TV test pattern |
| 49% | SEE | 3 | Word in the first line of the U.S. national anthem |
| 49% | PREAMBLE | 8 | First part of the U.S. Constitution |
| 48% | EAST | 4 | Part of the U.S. that's usually first with election returns |
| 48% | SHRIVER | 7 | First director of the U.S. Peace Corps |
| 48% | DELAWARE | 8 | The First State of the US |
| 47% | ABE | 3 | Nickname of the first Republican president of the US |
| 47% | ASTORIA | 7 | Oregon city that was the first permanent U.S. settlement west of the Rockies |
| 47% | STKITTS | 7 | Site of the first British colony in the Caribbean, 1624 |
| 47% | ELANA | 5 | ___ Meyers, who in 2015 was part of the first world champion team from the US in women's bobsled |
| 46% | HARRIS | 6 | The first female vice president-elect of the US |
| 46% | BOAC | 4 | Airline mentioned in the first line of the Beatles' "Back in the U.S.S.R." |
| 46% | DAYTIMEMEAWARDS | 15 | Prizes won by Acadia National Park for the first sight of sunrise in the U.S.? |