| 100% | REEVE | 5 | Four-time portrayer of Clark Kent |
| 59% | REEVE | 5 | Four-time Kent portrayer |
| 55% | LOISLANE | 8 | Cohort of Clark Kent |
| 54% | OLSEN | 5 | Jimmy ___ (friend of Clark Kent) |
| 51% | DIANELANE | 9 | Portrayer of Martha Kent in "Justice League" |
| 50% | REPORTER | 8 | Day job of Clark Kent when he's not Superman |
| 48% | LANALANG | 8 | High school girlfriend of Clark Kent in the Superman comic book series |
| 48% | SARAHPAULSON | 12 | Portrayer of Marcia Clark on "American Crime Story": 2 wds. |
| 48% | OCTET | 5 | Group four times the size of a duo |
| 47% | LANG | 4 | Lana —, high school girlfriend of Clark Kent in the Superman comic book series |
| 46% | ASIGN | 5 | Petula Clark's "___ of the Times" |
| 45% | NOEL | 4 | Word sung four times before "Born is the King of Israel" |
| 45% | ALE | 3 | Drink mentioned four times in the prologue of "The Canterbury Tales" |
| 44% | LANE | 4 | Actress Diane who plays Clark Kent's mother in "Man of Steel" |
| 44% | EON | 3 | One of four in the geologic time scale |
| 44% | CAVILL | 6 | Henry —, actor who played Clark Kent in 2013 action film Man of Steel |
| 43% | AST | 3 | Time zone four hrs. ahead of 33-Down |
| 43% | ASIGN | 5 | "___ of the Times" (1966 Petula Clark hit) |
| 42% | HATE | 4 | Word repeated four times in the chorus of Taylor Swift's "Shake It Off" |
| 42% | EONS | 4 | The Earth has existed for four of these time periods |
| 42% | JENNIFER | 8 | With 48-Across, portrayer of Katniss Everdeen, the highest-grossing action heroine of all time |
| 42% | JLO | 3 | Four-time platinum album of 2001 |
| 42% | LEON | 4 | Four-time Grammy winners Kings of ___ |
| 42% | WOODS | 5 | Four-time winner of the Masters |
| 42% | LEON | 4 | Four-time Grammy winners Kings of __ |
| 41% | BLACKFRIDAY | 11 | Time of annual madness ... or a hint to four squares in this puzzle |
| 41% | AGASSI | 6 | Four-time winner of the Australian Open |
| 41% | DOIDARE | 7 | Phrase repeated four times in T.S. Eliot's "The Love Song of J. Alfred Prufrock" |
| 40% | EAGLE | 5 | Creature whose eyesight has four to five times the acuity of humans |