| 100% | FAMILYGUY | 9 | Fox animated series created by Seth MacFarlane: 2 wds. |
| 59% | THEORVILLE | 10 | Sci-fi TV series created by and starring Seth MacFarlane as Captain Ed Mercer (2 wds.) |
| 56% | FAMILYGUY | 9 | Fox animated series with a mother named Lois (voiced by Alex Borstein): 2 wds. |
| 48% | FAMILYGUY | 9 | Fox animated series that wrapped its 20th season in 2022: 2 wds. |
| 48% | THESIMPSONS | 11 | Fox animated series that wrapped its 33rd season in 2022: 2 wds. |
| 47% | GUY | 3 | "___ Guy," animated sitcom created by Seth MacFarlane |
| 46% | GUY | 3 | "Family ___," American animated sitcom created by Seth MacFarlane |
| 46% | AMERICANDAD | 11 | Animated show in which the father (voiced by Seth MacFarlane) works for the CIA: 2 wds. |
| 46% | FAMILYGUY | 9 | Seth MacFarlane animated series featuring the voices of 15-Across, 26-Across, and 34-Across that debuted in 1999 (2 wds.) |
| 46% | DAALI | 5 | "___ G Show", the satirical television series created by actor Sacha Baron Cohen: 2 wds. |
| 45% | THEMARVELOUS | 12 | "___ Mrs. Maisel," Amazon Prime's Emmy-winning series created by Amy Sherman-Palladino: 2 wds. |
| 45% | ONETREE | 7 | "___ Hill," American teen drama TV series created by Mark Schwahn starring Chad Michael Murray: 2 wds. |
| 45% | INLIVING | 8 | "___ Color," '90s sketch comedy series created by Keenen Ivory Wayans which featured Jamie Foxx: 2 wds. |
| 43% | AMYPOEHLER | 10 | "Parks and Recreation" actress who voices Duncan and Annie Harris on the new Fox animated series "Duncanville": 2 wds. |
| 43% | GLENNQUAGMIRE | 13 | Neighbor of Peter Griffin voiced by Seth MacFarlane (2 wds.) |
| 43% | GUY | 3 | "Family ___," 1999 sitcom created by Seth MacFarlane |
| 43% | GUY | 3 | "Family ___" (1999 sitcom created by Seth MacFarlane) |
| 42% | TED | 3 | Potty-mouthed stuffed animal created by Seth MacFarlane |
| 42% | EDD | 3 | "Ed, ___, n Eddy," animated series created by Danny Antonucci |
| 41% | IRONFIST | 8 | Marvel web television series created for Netflix by Scott Buck based on a martial arts expert: 2 wds. |
| 41% | ALPHAHOUSE | 10 | Short-lived political satire series created by 27-Across starring John Goodman (2 wds.) |
| 40% | FAMILYGUY | 9 | Animated TV series featuring the voices of Seth MacFarlane and 43-Across (2 wds.) |
| 40% | FAMILYGUY | 9 | Animated TV series featuring the voices of Seth MacFarlane and 42-Across (2 wds.) |
| 40% | TOM | 3 | "___ and Jerry," American animated series created by William Hanna and Joseph Barbera |
| 39% | ACADEMYAWARDS | 13 | Seth MacFarlane hosted them in 2013: 2 wds. |
| 39% | SOUTHPARK | 9 | Animated series on Comedy Central: 2 wds. |
| 38% | SHERLOCKHOLMES | 14 | Fictional detective created by Arthur Conan Doyle: 2 wds. |
| 38% | HARRYPOTTER | 11 | Orphan wizard created by J.K. Rowling: 2 wds. |
| 38% | JAMESBOND | 9 | Spy created by Ian Fleming: 2 wds. |
| 38% | THESIMPSONS | 11 | Fox animated sitcom now in its 30th season: 2 wds. |