| 100% | GOYA | 4 | Francisco with frescoes |
| 54% | GOYA | 4 | Francisco who painted frescoes |
| 54% | ASSISI | 6 | Italian town with frescoes by Giotto |
| 49% | ASSISI | 6 | Italian town with Giotto frescoes |
| 49% | CASTRO | 6 | San Francisco neighborhood, with "the" |
| 49% | BAY | 3 | San Francisco area, with "the" |
| 48% | PALO | 4 | With 5-Across, city on San Francisco Bay |
| 48% | SANTA | 5 | With 17 Down, city north of San Francisco |
| 47% | ROXIE | 5 | Historic San Francisco theater, with "the" |
| 47% | CASTRO | 6 | Historic San Francisco district, with "the" |
| 47% | LASTSUPPER | 10 | Leonardo da Vinci fresco, with "The" |
| 46% | CABLE | 5 | With 7-Across, vehicles in a San Francisco museum |
| 46% | COITTOWER | 9 | San Francisco monument with working-life murals |
| 46% | BAY | 3 | ___ Area (region with San Francisco and Oakland) |
| 46% | SCHOOLOFATHENS | 14 | Raphael fresco depicting Greek philosophers, with "The" |
| 45% | MUNI | 4 | San Francisco's public transit system, with "the" |
| 45% | AREA | 4 | Bay ___ (region with San Francisco and San Jose) |
| 45% | FOG | 3 | Weather condition associated with London and San Francisco |
| 45% | NOB | 3 | ___ Hill, San Francisco neighborhood with many luxury hotels |
| 44% | ARENA | 5 | Padua's ___ Chapel, with a renowned Giotto fresco |
| 41% | CASTRO | 6 | San Francisco neighborhood with the GLBT Historical Society Museum, with "the" |
| 41% | CASTRO | 6 | Noted San Francisco L.G.B.T.-friendly neighborhood, with “the” |
| 38% | ATTILA | 6 | Raphael painted a fresco of him having an audience with Pope Leo I |
| 34% | NINERS | 6 | San Francisco-based athletes with a team name inspired by the California Gold Rush, for short |
| 34% | STEVEYOUNG | 10 | Left-handed quarterback who won the 1995 Super Bowl with the San Francisco 49ers: 2 wds. |
| 33% | GIOTTOS | 7 | Some famed frescoes |
| 33% | MURALS | 6 | Frescos |
| 33% | MURAL | 5 | Fresco |
| 33% | JIMMY | 5 | ___ Johnson, former NFL cornerback who spent his entire career with San Francisco 49ers from 1961 to 1976 |
| 33% | VERTIGO | 7 | 1958 thriller in which Jimmy Stewart plays an ex-San Francisco detective with a fear of heights |