| 100% | FRELENG | 7 | Friz —, animated cartoon director who created characters Yosemite Sam and Speedy Gonzalez |
| 55% | JONES | 5 | Chuck —, animated cartoon director who created characters Wile E Coyote and Marvin Martian |
| 38% | AVERY | 5 | Tex —, film cartoon director who created the character Daffy Duck |
| 35% | ELSA | 4 | Animated character who can create snow and ice |
| 30% | AVERY | 5 | Tex —, animator and film director who created canine character Droopy |
| 30% | TYLER | 5 | Actor and director Perry, who created the Madea character |
| 30% | MAXFLEISCHER | 12 | Cartoonist who created characters Koko the Clown and Betty Boop |
| 27% | ELSA | 4 | Animated character who created the snowman Olaf |
| 26% | ABE | 3 | Animated character who first appeared in the Simpsons short "Grandpa and the Kids" |
| 25% | LOUISAMAYALCOTT | 15 | Author who created the characters named by the starts of 17-, 24-, 49- and 61-Across |
| 25% | YOSEMITE | 8 | ___ Sam, "Looney Tunes" character who sports an iconic fiery red mustache and beard |
| 25% | ABE | 3 | "Simpsons" character who first appeared in the cartoon "Grampa and the Kids" |
| 25% | ANTONCHEKHOV | 12 | Russian writer who created the characters played by 15-Across, 40-Across, and 45-Across in "The Seagull" |
| 24% | MADEA | 5 | Tyler Perry character who has appeared in 11 live-action films and one animated film |
| 24% | AVERY | 5 | Tex —, director of cartoon features who created Daffy Duck |
| 23% | TYLER | 5 | Actor/director Perry who created the character Madea |
| 23% | AVADUVERNAY | 11 | "Selma" director who created "Queen Sugar": 2 wds. |
| 23% | DISNEY | 6 | Company that created the characters who develop at the starts of the starred and double-starred entries |
| 23% | DOO | 3 | Scooby-___, animated cartoon character |
| 23% | LEE | 3 | Director Daniels who co-created the TV shows "Empire" and "Star" |
| 23% | GARRYMARSHALL | 13 | Director/producer/actor who created "Happy Days," developed 18-Across, and directed 44-Across: 2 wds |
| 22% | DASHIELL | 8 | Hammett who created Nick and Nora |
| 22% | TESS | 4 | Gerritsen who created Rizzoli and Isles |
| 22% | NICKPARK | 8 | Animator who created Wallace and Gromit |
| 22% | CHARLESSCHULZ | 13 | Cartoonist who created Snoopy and Woodstock |
| 22% | AAMILNE | 7 | Author who created Heffalumps and Woozles |
| 22% | ERLE | 4 | Author who created Della and Perry |
| 22% | ANIMATOR | 8 | Person who creates Disney cartoons, say |
| 22% | WES | 3 | ___ Craven, director who created the "Nightmare on Elm Street" film franchise |
| 22% | NELSON | 6 | Lee ___, a fictional character created by comedian Simon Brodkin who has pranked the likes of Theresa May and Kanye West |