| 100% | SRTA | 4 | Frl., to Francisco |
| 68% | GATO | 4 | Feline, to Francisco |
| 68% | PRIMERO | 7 | First, to Francisco |
| 63% | AMIGAS | 6 | Female friends, to Francisco |
| 60% | SAN | 3 | Lead-in to Francisco or Pedro |
| 55% | RIA | 3 | San Francisco Bay, to geologists |
| 55% | GOLDENGATE | 10 | Entrance to San Francisco Bay |
| 54% | BAYBRIDGE | 9 | Structure connecting San Francisco to Oakland |
| 54% | SAN | 3 | Lead-in to Fernando or Francisco |
| 52% | FRANCO | 6 | Francisco __, ruled Spain from the '30s to the '70s |
| 52% | GOLDRUSH | 8 | Miner stampede to San Francisco in 1849 |
| 52% | SSE | 3 | Dir. from San Francisco to Santa Cruz |
| 52% | MISSIONDISTRICT | 15 | San Francisco neighborhood home to Calle 24 |
| 51% | UPCOAST | 7 | From Los Angeles to San Francisco, e.g. |
| 46% | LEE | 3 | ___ Highway, old auto route from New York City to San Francisco |
| 44% | BEIRUT | 6 | Foreign capital whose name sounds like a water passage to San Francisco |
| 44% | PONYEXPRESS | 11 | Its first delivery went from St. Joseph, Missouri, to San Francisco (1860) |
| 43% | BAYLORE | 7 | Legends of San Francisco's body of water? (... to a school in Texas) |
| 41% | ENE | 3 | San Francisco-to-Oakland dir. |
| 41% | SANTACLARA | 10 | University city in California, US, home to American football team the San Francisco 49ers |
| 40% | ESE | 3 | San Francisco-to-Las Vegas dir. |
| 40% | ODE | 3 | "___ to My Shoes" (Francisco X. Alarcon poem) |
| 40% | SAN | 3 | "Fake Tales of ___ Francisco," song by the Arctic Monkeys that refers to a Californian city |
| 39% | SAN | 3 | __ Francisco |
| 38% | AMIGO | 5 | Friend of Francisco |
| 38% | PACO | 4 | Nickname for Francisco |
| 38% | GOYA | 4 | Spanish painter Francisco |
| 38% | SAN | 3 | Diego or Francisco |
| 38% | GOYA | 4 | Spanish artist Francisco |
| 38% | GOYA | 4 | Maja painter Francisco |