| 100% | LOUIE | 5 | FX series frequently set in the Comedy Cellar |
| 51% | FARGO | 5 | FX series set in the Great Plains |
| 49% | THEAMERICANS | 12 | FX spy series set in the 1980s: 2 wds. |
| 47% | THEGOLDBERGS | 12 | ABC comedy series set in the 1980s: 2 wds. |
| 42% | TIMETRAX | 8 | 1990s series initially set in the year 2193 |
| 41% | GLEE | 4 | US television comedy-drama series set in the fictitious William McKinley High School |
| 41% | ARTURO | 6 | Castro who created and starred in the Comedy Central series “Alternatino” |
| 41% | SUNNY | 5 | "It's Always ___ in Philadelphia," FX comedy series that is the longest-running live-action comedy series in U.S. history |
| 41% | GREENWING | 9 | 2000s Channel 4 television comedy series set in the fictional East Hampton Hospital Trust |
| 41% | SCHITTS | 7 | "___ Creek," sitcom that set a record for the most Emmy wins for a comedy series in a single year in 2020 |
| 41% | POSE | 4 | 2018-2021 FX series set in New York |
| 40% | DAN | 3 | Actor Stevens who stars in the FX series "Legion" |
| 40% | IRAQWAR | 7 | Setting of the FX series "Over There" |
| 40% | FUTURAMA | 8 | Animated series set in the 31st century |
| 39% | FUTURAMA | 8 | Comedy Central cartoon set in the year 3000 |
| 39% | ATLANTA | 7 | Donald Glover series set in the South |
| 38% | MATTHEWRHYS | 11 | Portrayer of Philip Jennings in the FX series "The Americans": 2 wds. |
| 38% | KERIRUSSELL | 11 | Portrayer of Elizabeth Jennings in the FX series "The Americans": 2 wds. |
| 38% | FUTURAMA | 8 | Matt Groening series set in the 31st century |
| 38% | RACHEL | 6 | Bloom who played Rebecca in The CW comedy-drama series "Crazy Ex-Girlfriend" |
| 37% | STRANGERTHINGS | 14 | Netflix horror series set in the 1980s: 2 wds. |
| 37% | WESTWING | 8 | The __, TV series set in the White House |
| 37% | THING | 5 | Disembodied hand in US television comedy series The Addams Family |
| 37% | BABYLON5 | 8 | Sci-fi series set in the 23rd century |
| 37% | POSE | 4 | FX series for which Billy Porter won the 2019 Emmy for Outstanding Lead Actor in a Drama |
| 37% | STRANGER | 8 | __ Things, Netflix series set in the 1980s |
| 37% | GLEE | 4 | 2009-15 US television comedy-drama series set in the fictitious William McKinley High School |
| 36% | HAM | 3 | West ___ United, English football team that is portrayed as AFC Richmond's fierce rival in the comedy series "Ted Lasso" |
| 36% | ALL | 3 | "___ in the Family," sitcom starring Carroll O'Connor which won four Emmy awards for Outstanding Comedy Series |