| 100% | MBA | 3 | G.W. Bush is the only president who earned one |
| 63% | MBA | 3 | Pres. George W. Bush was the only president to hold one of these degs. |
| 52% | MBA | 3 | Bush Jr. is the only U.S. president to hold one |
| 50% | PHD | 3 | Wilson was the only president with one |
| 47% | PATENT | 6 | Lincoln is the only U.S. president to have one |
| 47% | STATE | 5 | Washington is the only one named for a president |
| 46% | MBA | 3 | CFO's degree, maybe (Bush is the only president to have one) |
| 46% | WHIG | 4 | Fillmore was the last president who was one |
| 46% | PHD | 3 | Woodrow Wilson is the only U.S. president to have one |
| 46% | PHD | 3 | Woodrow Wilson was the only U.S. president to have one |
| 46% | EMMY | 4 | Courteney Cox was the only "Friends" star who never got one |
| 45% | AMI | 3 | "___ the only one who thinks this is a bad idea?" |
| 45% | AMI | 3 | "___ the only one who thinks this is funny?" (2 wds.) |
| 44% | LABORUNION | 10 | Ronald Reagan is the only U.S. president who was also president of a … |
| 42% | WASP | 4 | Martin Van Buren was the first president who wasn't one |
| 41% | IOWA | 4 | Hoover was the only president born there |
| 40% | TAFT | 4 | Only President who was also Chief Justice |
| 40% | PHD | 3 | Woodrow Wilson was the only president with this degree: Abbr. |
| 40% | TAFT | 4 | Only president who was also a chief justice |
| 39% | IPODS | 5 | Touches are the only ones still produced |
| 39% | FDR | 3 | President who said "The only thing we have to fear is fear itself": Abbr. |
| 38% | DOESNTEVERYBODY | 15 | "I can't be the only one, right?" |
| 38% | TEE | 3 | August is the only month that ends with one |
| 38% | YOUTOO | 6 | "And here I thought I was the only one" |
| 38% | WEDINTHEWHITEHOUSE | 18 | Cleveland: The only one who __ |
| 37% | CHUCKCONNORS | 12 | Actor who was one of only 13 athletes to play in both the NBA and the MLB (2 wds.) |
| 37% | WRITEWITHBOTHHANDS | 18 | Garfield: The only one who could __ |
| 37% | MBA | 3 | Degree held by only one U.S. president (George W. Bush) |
| 37% | BEARD | 5 | Dopey is the only one of the Seven Dwarfs without one |
| 37% | NEPAL | 5 | Its flag is the only non-rectangular one in the world |