| 100% | OLDMAN | 6 | Gary who plays the lead character in Slow Horses |
| 57% | TIMOTHEE | 8 | With 35-Across, "Little Women" actor who plays the lead character Paul Atreides in "Dune" |
| 56% | MELGIBSON | 9 | Actor who played the lead character, "Mad" Max Rockatansky in the 1979 film "Mad Max": 2 wds. |
| 56% | CLARKKENT | 9 | The lead character in "Smallville" who eventually becomes Superman, played by Tom Welling: 2 wds. |
| 51% | HERO | 4 | The lead character in a film or play |
| 49% | SPACEK | 6 | Sissy who played the lead in 1976's "Carrie" |
| 48% | DEMI | 4 | ___ Moore, actress who played the lead in "G. I. Jane" |
| 48% | TOM | 3 | Hiddleston who plays the title character in Loki |
| 48% | TIERNEY | 7 | Gene who played the title character in Laura |
| 48% | CHRISTIAN | 9 | Slater who plays the title character in "Mr. Robot" |
| 48% | TAMARA | 6 | Dobson who played the title character in “Cleopatra Jones” |
| 47% | JAIMIE | 6 | ___ Alexander who played the mysterious, tattooed lead in "Blindspot" |
| 47% | FELIX | 5 | Kammerer who plays the lead in 2022's "All Quiet on the Western Front" |
| 46% | VOSK | 4 | Jessica who played the lead role, Elphaba, in "Wicked" on Broadway in 2018-19 |
| 46% | ELLIEKEMPER | 11 | Actress who plays the lead role in 12-/24-Across: 2 wds. |
| 46% | LIVTYLER | 8 | "Armageddon" actress who played the lead singer's girlfriend Faye in 34-Across: 2 wds. |
| 46% | PESCI | 5 | Actor Joe who played the title character in "My Cousin Vinny" |
| 46% | RIK | 3 | Comedian Mayall who played the title character in Drop Dead Fred |
| 46% | CHRISTIANKANE | 13 | The actor who plays the lead character and genius Jacob Stone on "The Librarians": 2 wds. |
| 46% | ELISABETHMOSS | 13 | American actress who plays the lead role of Offred in the series in 18a: 2 wds. |
| 45% | EZRAMILLER | 10 | Actor who plays the title character in the new movie "The Flash": 2 wds. |
| 45% | CHACECRAWFORD | 13 | Actor who plays the key male character in "Gossip Girl": 2 wds. |
| 45% | RYAN | 4 | Meg —, actress who played the female lead in 2001 comedy Kate & Leopold |
| 45% | TOMHARDY | 8 | "Inception" actor who plays the title character in "Venom": 2 wds. |
| 45% | MARGOTROBBIE | 12 | "Babylon" actress who plays the title character in "Barbie": 2 wds. |
| 45% | HOLLAND | 7 | Tom ___, who plays the titular character in "Spider-Man: Homecoming" |
| 45% | SKYLAR | 6 | ___ Gaertner, actor who plays the character of Jonah Byrde in Netflix's "Ozark" |
| 45% | SOFIA | 5 | ___ Hublitz, actress who plays the character of Charlotte Byrde in Netflix's "Ozark" |
| 45% | LINNEY | 6 | Laura ___, actress who plays the character of Wendy Byrde in Netflix's "Ozark" |
| 45% | EMERY | 5 | Lisa ___, actress who plays the character of Darlene Snell in Netflix's "Ozark" |