| 100% | LTGEN | 5 | Geo. Washington was the U.S.'s first |
| 71% | GEORGE | 6 | __ Washington was the first US president |
| 65% | RENO | 4 | Janet who was the U.S.’s first female Attorney General |
| 64% | BASSALE | 7 | Its logo was the U.K.'s first registered trademark |
| 62% | UTAH | 4 | Where the U.S.'s first transcontinental railroad was completed (1869) |
| 59% | NBC | 3 | Its chimes were the first U.S. registered "sound mark" |
| 58% | HONDAACCORD | 11 | First car from a Japanese manufacturer to be made in the U.S. (1982) |
| 56% | RYANZIMMERMAN | 13 | Washington Nationals infielder who was the team's first ever draft pick in 2005 (2 wds.) |
| 56% | STU | 3 | Rasmussen who was the first openly transgender mayor in the U.S. |
| 55% | OBERLIN | 7 | Ohio college that was the first in the U.S. to admit women |
| 55% | RENO | 4 | Janet who was the first woman to serve as U.S. attorney general |
| 55% | YELLOWSTONE | 11 | First national park in the U.S. with parts in Wyoming that was featured in the movie "2012" |
| 55% | CARTOON | 7 | The Flintstones was the first US primetime __ |
| 55% | ENRICO | 6 | Caruso who was featured on the first public-radio broadcast in the U.S., in 1910 |
| 55% | ASTORIA | 7 | Oregon city that was the first permanent U.S. settlement west of the Rockies |
| 54% | FAYETTEVILLE | 12 | Where Senator Hiram Rhodes Revels, first African American to serve in the U.S. Congress, was born |
| 54% | ASTOR | 5 | The U.S.'s first multimillionaire |
| 54% | OBERLIN | 7 | Ohio college that was the first in the U.S. to award degrees to women |
| 53% | GUS | 3 | Skier Kenworthy who was one of the first out gay U.S. Winter Olympians |
| 53% | YOUR | 4 | "Go ___ Own Way," 1976 song by Fleetwood Mac that was their first top-ten hit in the U.S. |
| 52% | ALABAMA | 7 | Montgomery's state that was the first US state to recognize Christmas as a holiday in 1836 |
| 52% | RENO | 4 | Janet who was the first female US attorney general |
| 52% | ABBA | 4 | Band whose first hit in the US was "Waterloo" |
| 52% | RADIO | 5 | In 1922, Warren G. Harding became the first U.S. president to be broadcast over this |
| 51% | MILEYCYRUS | 10 | "Party in the U.S.A." singer whose first TV series lead role was on Disney's "Hannah Montana": 2 wds. |
| 51% | ERIC | 4 | Holder who was the first African-American US Attorney General |
| 51% | SIA | 3 | Australian whose first big hit in the US was "Chandelier" |
| 51% | ONE | 3 | ___ dollar bill, currency that has George Washington's portrait and is the oldest design in U.S. currency history |
| 51% | IKEA | 4 | Company that was the first in the U.S. to air a TV ad with a gay couple (1994) |
| 51% | ELANA | 5 | ___ Meyers, who in 2015 was part of the first world champion team from the US in women's bobsled |