| 100% | STARWARS | 8 | George Lucas sci-fi film series that debuted on May 25, 1977 (2 wds.) |
| 72% | STARWARS | 8 | George Lucas sci-fi film series that debuted in 1977 (2 wds.) |
| 66% | STARWARS | 8 | George Lucas space opera franchise that debuted on May 25, 1977 (2 wds.) |
| 56% | STARWARS | 8 | 1977 George Lucas film that launched a sci-fi franchise: 2 wds. |
| 41% | DOCTORWHO | 9 | BBC sci-fi series that debuted in 1963: 2 wds. |
| 39% | STARWARS | 8 | George Lucas's hugely popular sci-fi film franchise (2 wds) |
| 35% | THEXFILES | 9 | Sci-fi TV series that originally aired from 1993 to 2002: 2 wds. |
| 35% | ITTAKESATHIEF | 13 | Action-adventure series that debuted on January 9, 1968 (4 wds.) |
| 34% | BLACKMIRROR | 11 | Sci-fi TV series on Netflix that revolves around the effect of technology on people: 2 wds. |
| 33% | SAILORMOON | 10 | Manga series that debuted in 1992 featuring 18-Across, 25-Across, 34-Across, and schoolgirl Usagi Tsukino who transforms into the title character (2 wds.) |
| 33% | GODSPLAN | 8 | 2018 Drake track that debuted at #1 on the Billboard Hot 100: 2 wds. |
| 33% | MOSTLYGHOSTLY | 13 | R.L. Stine book series that might spook middle schoolers: 2 wds. |
| 32% | BUFFYSUMMERS | 12 | Title vampire slayer played by Sarah Michelle Gellar on a series that debuted 25 years ago this year (2 wds.) |
| 32% | BRAVENEWWORLD | 13 | 2020 Peacock sci-fi series that was based on an Aldous Huxley novel: 3 wds. |
| 31% | DOCUMENTARYNOW | 14 | IFC comedy series that spoofs films like "Grey Gardens" and "When We Were Kings": 2 wds. |
| 31% | STARTREKPICARD | 14 | Sci-fi series starring 16-Across and 34-Across that debuted on CBS All Access on January 23, 2020 (3 wds.) |
| 31% | HIGHESTIN | 9 | With 43-Across, 2019 Travis Scott song that debuted at #1 on the Billboard Hot 100: 2 wds. |
| 31% | AVATAR | 6 | Sci fi film that went really big |
| 30% | GIJOE | 5 | Sci-fi film based on a toy franchise, "___: The Rise of Cobra": 3 wds. |
| 30% | THENAMESAKE | 11 | Debut novel by 25-Across/27-Across that was adapted as a film starring Kal Penn and directed by Mira Nair (2 wds.) |
| 30% | FEARSTREET | 10 | R.L. Stine book series that might spook teenagers: 2 wds. |
| 30% | STARGATE | 8 | 1994 sci-fi film turned into a series on Showtime |
| 30% | LAUGHIN | 7 | Sketch comedy series that debuted on January 22, 1968 (Hyph.) |
| 30% | TRAININGDAY | 11 | 2017 TV series that's based on a Denzel Washington movie and stars Bill Paxton as a cop: 2 wds. |
| 30% | ASPACEODYSSEY | 13 | Subtitle of a classic sci-fi film that premiered in April 1968 (3 wds.) |
| 30% | ALIEN | 5 | 1979 sci-fi film that features Howard Hanson's "Symphony No. 2" |
| 29% | LILYPAD | 7 | Pond foliage that a frog might sit on: 2 wds. |
| 29% | LILYPAD | 7 | Floating plant that a frog might perch on: 2 wds. |
| 29% | SARAHCONNOR | 11 | Action hero played by 48-Across in a film series that began with 15-Across (2 wds.) |
| 29% | MISTERROGERS | 12 | With 40-Across, TV series for children that debuted on February 19, 1968 (2 wds.) |