| 100% | MEANY | 5 | George who was the first president of the A.F.L.-C.I.O. |
| 97% | MEANY | 5 | Labor leader George who was the first president of the A.F.L.-C.I.O. |
| 55% | SEAN | 4 | Parker who was the first president of Facebook |
| 55% | VAL | 3 | Basketball Hall of Famer Ackerman who was the first president of the WNBA |
| 53% | VALACKERMAN | 11 | 2021 Basketball Hall of Fame inductee who was the first president of the WNBA (2 wds.) |
| 52% | KENNEDY | 7 | 35th President of the United States, John F. ___, who was shot twice, while inside a vehicle in a procession |
| 51% | SAMSMITH | 8 | "Stay With Me" singer who was a first-time Grammy nominee for Record of the Year (and won): 2 wds. |
| 51% | JACKIESTILES | 12 | 2016 Women's Basketball Hall of Fame inductee who was the first Division I player to score over 1,000 points in a season: 2 wds. |
| 51% | DANTON | 6 | Georges who was a key member of the Jacobin Club, along with Robespierre and Marat |
| 51% | FAE | 3 | Baby who was the first infant subject of a xenotransplant procedure in 1984 |
| 50% | CZECH | 5 | Nationality of a poet and playwright who became the first president of his country |
| 50% | LISALESLIE | 10 | L.A. Sparks player who was the first to dunk in a W.N.B.A. game |
| 50% | ALTHEA | 6 | Gibson who was the first person of color to win a tennis Grand Slam event |
| 49% | UMW | 3 | Affiliate of the A.F.L.-C.I.O. |
| 49% | ALTHEAGIBSON | 12 | Tennis great who was the first person of color to win a Wimbledon championship (2 wds.) |
| 48% | ANNPRESTON | 10 | American physician and activist who was the first female dean of a medical school in the world: 2 wds. |
| 48% | BILL | 4 | ___ Clinton, 42nd President of the United States who was a lawyer |
| 48% | LABOR | 5 | The "L" of A.F.L.-C.I.O. |
| 47% | SAHLE | 5 | ___-Work Zewde, Ethiopian politician who is the first woman to serve as the President of Ethiopia |
| 47% | DEVI | 4 | Bidya ___ Bhandari, Nepalese politician who is the first woman to serve as the President of Nepal |
| 47% | ELLEN | 5 | Broidy who was a co-organizer of the first gay pride march |
| 47% | MEANY | 5 | First A.F.L.-C.I.O. president |
| 47% | RETTON | 6 | Gymnast Mary Lou who was the first woman to appear on the front of a Wheaties box |
| 47% | EVEL | 4 | First name of the role George Hamilton played in a 1971 movie where he stated "I am the last gladiator in the new Rome" |
| 47% | LAHR | 4 | First actor who sang "If I Were King of the Forest" |
| 47% | TOM | 3 | Landry who was the first coach of the Cowboys |
| 47% | MARIA | 5 | ___ Mitchell, astronomer who was the first female professor of astronomy and the first American to discover a comet |
| 47% | ANNEMURRAY | 10 | "You Needed Me" singer who was made a Companion of the Order of Canada in 1984: 2 wds. |
| 47% | LISALESLIE | 10 | Basketball Hall of Fame inductee who was the first player to dunk in a WNBA game: 2 wds. |
| 46% | FORD | 4 | Gerald ___, 38th President of the United States of America who was also a lawyer |