| 100% | SWEAROFF | 8 | Give up something forever: 2 wds. |
| 58% | CRYUNCLE | 8 | Give up in a fight: 2 wds. |
| 57% | GOPRO | 5 | Give up one's amateur status: 2 wds. |
| 57% | ATIT | 4 | "Keep ___!" ("Don't give up!"): 2 wds. |
| 56% | PEPTALKS | 8 | Motivational "don't give up" speeches: 2 wds. |
| 53% | GOPRO | 5 | Give up amateur status (2 wds.) |
| 53% | HANDOVER | 8 | Give up control of (2 wds.) |
| 53% | TINATURNER | 10 | "Private Dancer" singer who gave up US citizenship in 2013: 2 wds. |
| 52% | JOHNHUSTON | 10 | "The African Queen" director who gave up US citizenship in 1964: 2 wds. |
| 51% | IWONT | 5 | Jason Mraz's "___ Give Up": 2 wds. |
| 51% | TERRYGILLIAM | 12 | Monty Python comedian and filmmaker who gave up US citizenship in 2006: 2 wds. |
| 51% | CEDED | 5 | Gave up something |
| 50% | SACRIFICE | 9 | Give up something precious |
| 49% | SACRIFICE | 9 | Give up something you care about |
| 48% | OKOK | 4 | "All right, all right ... I give up": 2 wds. |
| 48% | ONUS | 4 | David Soul's "Don't Give up ___" (2 wds.) |
| 48% | SACRIFICE | 9 | Give up something for Lent, forgo it |
| 48% | SACRIFICE | 9 | Give up something valued, at considerable cost |
| 47% | ZACKBRITTON | 11 | New York Yankees pitcher who gave up the walk-off home run in the 30-Across game ( 2 wds.) |
| 46% | ANOD | 4 | "And giving ___, up the chimney he rose" (2 wds.) |
| 46% | ITIN | 4 | Pack ___ (give up): 2 wds. |
| 45% | FORSAKE | 7 | Give up or renounce something valued |
| 45% | ISEE | 4 | 2 wds to show understanding of something |
| 45% | ITA | 3 | "Call ___ day!" (give up): 2 wds. |
| 44% | OBSERVELENT | 11 | Give something up, perhaps |
| 43% | BENTDOWN | 8 | Leaned over to pick something up: 2 wds. |
| 41% | SACRIFICE | 9 | To give up or lose something for better reasons |
| 41% | OKYOUWIN | 8 | "Fine! I give up!" (3 wds.) |
| 41% | LENT | 4 | Period to give something up |
| 41% | AGREETO | 7 | Give consent for: 2 wds. |