| 100% | JACKIEOPOSITIVE | 15 | Good attribute of a former first lady? |
| 64% | NURSEJACKIEO | 12 | Help a former first lady feel better? |
| 56% | HILLARY | 7 | ___ Clinton, former First Lady who won a Grammy for Best Spoken Word album in 1997 |
| 52% | JACKIECHANGED | 13 | Former first lady sporting a different outfit? |
| 50% | LAURABUSH | 9 | Former First Lady with a November birthday (2 wds.) |
| 50% | MICHELLEOBAMA | 13 | Former First Lady with a January birthday (2 wds.) |
| 50% | INES | 4 | ___ Mendoza, former first lady of Puerto Rico |
| 49% | RAISA | 5 | ___ Gorbachev, former first lady of the Soviet Union |
| 48% | CARLA | 5 | Singer/model Bruni who is the former First Lady of France |
| 47% | JACKIEKENNEDY | 13 | Former First Lady of the United States who was born in July (2 wds.) |
| 46% | BETTYFORD | 9 | Former first lady who co-wrote the memoir "The Times of My Life" (2 wds.) |
| 46% | BECOMING | 8 | 2018 memoir written by the former first lady of the US, Michelle Obama |
| 46% | OWN | 3 | "On My ___," 1958 book by the former first lady of the US, Eleanor Roosevelt |
| 46% | THIS | 4 | "___ I Remember," 1949 book by the former first lady of the US, Eleanor Roosevelt |
| 44% | IMELDA | 6 | ___ Marcos, longtime first lady of the Philippines with a notorious shoe collection |
| 44% | HOUSE | 5 | "A White ___ Diary," 1970 book written by the former first lady of the US, Lady Bird Johnson |
| 44% | MICHELLE | 8 | ___ Obama, former first lady of the United States who cameoed in an episode of "Parks and Recreation" |
| 43% | DISSEDHILLARY | 13 | What the First Lady's critics did over a bottle of bathtub gin? |
| 43% | MICHELLE | 8 | Beatles song and name of a US first lady |
| 43% | NANCYREAGAN | 11 | First Lady of the United States (1981-1989) who wrote "To Love a Child": 2 wds. |
| 43% | BESS | 4 | Former First Lady |
| 43% | MAMIE | 5 | Former first lady |
| 42% | LAURA | 5 | Former First Lady Bush |
| 42% | LOU | 3 | Former First Lady Hoover |
| 42% | OBAMA | 5 | Former First Lady Michelle |
| 42% | IDA | 3 | Former first lady McKinley |
| 42% | BESS | 4 | Former First Lady Truman |
| 42% | MICHELLEOBAMA | 13 | Former First Lady and "Becoming" author who was on the cover of the Winter 2021/22 issue of Vogue Knitting: 2 wds. |
| 42% | HUE | 3 | Attribute of a color |
| 42% | EGO | 3 | Attribute of a bighead |