| 100% | PTOLEMY | 7 | Greek, posited a geocentric theory of the universe |
| 58% | PTOLEMY | 7 | Astronomer with a geocentric model of the universe |
| 52% | BIGBANG | 7 | Theory of the universe, or a hint to the starts of 17-Across and 7-, 10-, 35- and 40-Down |
| 48% | BIGBANG | 7 | Scientific theory of the universe's beginning |
| 47% | BIGBANG | 7 | A theory that explains the origin of the universe |
| 43% | DEIST | 5 | Adherent of the clockwork universe theory |
| 43% | YLEM | 4 | Primordial matter of the universe, according to the Big Bang theory |
| 42% | LOCKE | 5 | Philosopher John who posited a theory of social contract |
| 42% | BIGBANG | 7 | One of the theories of how the universe began |
| 41% | ALPHA | 5 | Greek equivalent of the letter A |
| 40% | IOTA | 4 | Vowel-rich name of the English word for a Greek vowel |
| 40% | BADGIRLFRIEND | 13 | Theory of a Deadman song with the lyric "She's naughty to the end" |
| 40% | OMEGA | 5 | Last letter of the Greek alphabet that's shaped like a horseshoe |
| 40% | PARADIGMSHIFT | 13 | Transition to a heliocentric model of the universe, e.g. |
| 40% | HALDANE | 7 | A proposer of the primordial soup theory, John __ |
| 39% | PSI | 3 | Greek letter spelled out at the start of a Beatles title? |
| 39% | DELTA | 5 | Greek letter that's also the name of a US airline |
| 39% | PHI | 3 | Greek letter, or the first three letters of a Pennsylvania city |
| 39% | COSMIC | 6 | Of the universe |
| 38% | XXXXXX | 6 | First part of a name in the "Star Wars" universe |
| 38% | DELTA | 5 | Airline that's also the name of a Greek letter |
| 38% | DELTA | 5 | Area at the mouth of a river or a Greek letter |
| 37% | LETHE | 5 | Oblivion, in Greek ... and the name of a river in Greek mythology |
| 37% | BIGBANG | 7 | Theory that explains the creation of our universe |
| 37% | ODYSSEUS | 8 | A legendary Greek featured in Homer's epic poem, who was the King of Ithaca |
| 37% | YLEM | 4 | Protomatter of the universe |
| 37% | RIM | 3 | Edge of the universe |
| 37% | SPACEBARONS | 11 | Masters of the Universe? |
| 37% | BIGBANG | 7 | Beginning of the universe |
| 37% | GOD | 3 | Creator of the universe |