| 100% | ISTOO | 5 | Greta Thunberg's "No One ___ Small to Make a Difference" |
| 92% | ISTOO | 5 | Greta Thunberg book "No One ___ Small to Make a Difference" |
| 74% | NOONE | 5 | Who is "too small to make a difference," per a Greta Thunberg book title |
| 53% | GRETATHUNBERG | 13 | Swedish environmental activist who wrote "No One Is Too Small to Make a Difference" and who turns 18 today (2 wds.) |
| 52% | SPLASH | 6 | An Olympic diver hopes to make a small one |
| 47% | MINUSSIGN | 9 | Need to make a difference |
| 47% | POWERLESS | 9 | Unable to make a difference |
| 47% | AVA | 3 | "For a film to be made is a small miracle. And sometimes it's a large one" speaker DuVernay |
| 46% | AFFECT | 6 | Make a difference to |
| 46% | AFFECTING | 9 | Making a difference to someone |
| 45% | SWEEPSTAKES | 11 | One way to make a million |
| 45% | ROAST | 5 | One way to make a chicken |
| 45% | BALLHOG | 7 | One unlikely to make a pass |
| 45% | LISP | 4 | One way to make a sinner thinner |
| 45% | LOP | 3 | One way to make a bough break |
| 45% | AFFECT | 6 | Influence, make a difference to |
| 44% | HEADBACK | 8 | Make one's way to a previous location |
| 44% | STOLENBASE | 10 | One has to make a run for it |
| 43% | BEINGLIKEEVERYONEELSE | 21 | ''No one ever made a difference by __'' |
| 42% | RUNSINCIRCLES | 13 | Makes no progress, and a hint to this puzzle's theme |
| 42% | GARLAND | 7 | Pine needles are wired together to make a long one |
| 41% | MEAT | 4 | *Vegetarian's no-no ... or a word made by changing one letter of 34a |
| 41% | PINTWEAKS | 9 | Mystery drama series about making small adjustments to one's ATM code? |
| 40% | DEVIL | 5 | Dicey one to make a deal with |
| 40% | TWEAKS | 6 | Makes small, final changes to a design |
| 39% | DENTIST | 7 | One who tries to make a good impression |
| 39% | UP/DOWNSIDE | 11 | One aspect to consider in making a decision |
| 39% | EYELASH | 7 | Make a wish over this small facial hair to make it come true |
| 39% | WHISTLE | 7 | Small device blown to make a dog come back |
| 38% | TOOLITTLETOOLATE | 16 | Not enough, and without the urgency, to make a difference … or a literal hint to 18-, 30-, 38- and 48-Across |