| 100% | BARNARDO | 8 | Guard who speaks the first line in Hamlet |
| 57% | WHOSTHERE | 9 | This two-word phrase is the first line in Hamlet |
| 45% | KLAYTHOMPSON | 12 | Warriors guard who's the first player in NBA history to score 60 points in under 30 minutes of play: 2 wds. |
| 45% | WHOSTHERE | 9 | The first line of Shakespeare's Hamlet |
| 44% | STEPHENCURRY | 12 | Warriors point guard who became the NBA's first unanimous MVP in 2016: 2 wds. |
| 44% | SCAR | 4 | Disney villain who said, "I was first in line . . . until the little hairball was born" |
| 44% | ZENDAYA | 7 | Her character Chani says the first lines in 2021's Dune |
| 42% | RHYNEHOWARD | 11 | University of Kentucky guard who was selected by the Atlanta Dream as the first overall pick in the 2022 WNBA draft (2 wds.) |
| 42% | NEXT | 4 | Word to the first in line |
| 42% | IMNEXT | 6 | Cry from the first in line |
| 41% | ELMO | 4 | Muppet who speaks in the third person |
| 40% | LAIKA | 5 | Dog who was the first animal in space |
| 40% | SHEPARD | 7 | Alan who was the first American in space |
| 40% | ELDEST | 6 | First in line to the throne |
| 40% | HEIR | 4 | First in line to the throne |
| 40% | YODA | 4 | Someone who speaks like the quote in 25-Across |
| 40% | YURI | 4 | Gagarin who was the first human in outer space |
| 40% | ELDEST | 6 | First in line for the throne, perhaps |
| 39% | AARON | 5 | First in ''Who's Who in the Bible'' |
| 39% | AARON | 5 | First ''Who's Who in the Bible'' entry |
| 39% | LEO | 3 | First to speak in ''Gone With the Wind'' |
| 39% | LAMELOBALL | 10 | Hornets point guard who posted his first triple-double as a teenager in 2021, the youngest ever in the NBA: 2 wds. |
| 39% | RHYME | 5 | What the first, second and fifth lines in a limerick do |
| 39% | AGO | 3 | Adverb in the first line of the Gettysburg Address |
| 39% | YURI | 4 | Cosmonaut Gagarin who was the first person in space |
| 39% | ALAN | 4 | Astronaut Shepard who was the first American in space |
| 39% | MAE | 3 | Jemison who was the first Black woman in space |
| 39% | JEMISON | 7 | Mae who was the first Black woman in space |
| 39% | OCHOA | 5 | Astronaut Ellen who was the first Latina in space |
| 39% | THIEL | 5 | Peter who was the first outside investor in Facebook |