| 100% | POTTER | 6 | Harry __, title character of a series by JK Rowling |
| 53% | LOLITA | 6 | Title character of a controversial book by Nabokov |
| 50% | RAMONA | 6 | Title character in a series of Beverly Cleary books |
| 50% | SHREK | 5 | Title character in a series of four DreamWorks animated films |
| 47% | LAYLA | 5 | Title character of a song inspired by both a seventh-century Persian story and George Harrison's then-wife |
| 47% | HARLOWE | 7 | Clarissa —, title character of a 1748 epistolary novel by Samuel Richardson subtitled the History of a Young Lady |
| 46% | ANDOR | 5 | Title character played by Diego Luna in a "Star Wars" TV series |
| 45% | LASSIE | 6 | Female character of old TV played by a series of male performers |
| 45% | MILO | 4 | ___ Murphy, title character of a Disney series about a descendant of "Murphy's law" who wears a red striped sweater vest |
| 45% | PETER | 5 | Title character of a Prokofiev favorite |
| 45% | BORAT | 5 | Title character of a 2006 mockumentary |
| 45% | EXORCIST | 8 | Title character of a Blatty novel |
| 45% | AIDA | 4 | Title character of a Verdi opera |
| 44% | LILO | 4 | Title character of a 2002 Disney film |
| 44% | MORRISCHESTNUT | 14 | Actor who plays the title character of 47-Across in a CBS series that premiered in January: 2 wds. |
| 44% | DIEGO | 5 | Title character of a "Dora the Explorer" spinoff |
| 44% | DARKO | 5 | Title character of a Jake Gyllenhaal cult classic |
| 44% | APU | 3 | Title character of a Satyajit Ray film trilogy |
| 44% | GREGHEFFLEY | 11 | Main character of the "Diary of a Wimpy Kid" series by Jeff Kinney (2 wds.) |
| 43% | ZOOLANDER | 9 | Dimwitted title character of a 2001 comedy |
| 43% | SARA | 4 | Sister ___, title character of a 1970 film |
| 43% | CRUELLA | 7 | Disney-reboot title character whose mother is pushed off a cliff by a pack of Dalmatians |
| 43% | ANANG | 5 | Title character of a 1988 They Might Be Giants song |
| 43% | ALF | 3 | Furry alien title character of a 1980s sitcom |
| 43% | ALF | 3 | Furry title character of a 1986-1990 sitcom |
| 43% | THEWASP | 7 | Winged title character of a 2018 Marvel movie |
| 43% | LILO | 4 | Hawaiian title character of a 2002 Disney film |
| 43% | BONZO | 5 | Pajama-clad title character of a '51 film |
| 42% | AQUATEEN | 8 | Any of three title characters in a long-running Cartoon Network series |
| 40% | SONICTHE | 8 | With 42-Across, speedy blue title character of a 2020 film: 2 wds. |