| 100% | CRIPPEN | 7 | Hawley Harvey —, US doctor; first murder suspect to be captured with the aid of wireless telegraphy |
| 31% | STTERESA | 8 | First woman to be named Doctor of the Church, briefly |
| 31% | STTERESA | 8 | First woman to be made doctor of the Roman Catholic Church |
| 29% | REEL | 4 | Dance that was first referred to in the 1590 witchcraft trial of Doctor Fian in "Edenbrough", Scotland |
| 29% | COMINGINHOT | 11 | Arriving with great speed, and what the first words of the answers to the starred clues are doing? |
| 28% | IKEA | 4 | Company that was the first in the U.S. to air a TV ad with a gay couple (1994) |
| 28% | JACKSON | 7 | First US President to be the target of an assassination attempt (which failed), on January 30, 1835 |
| 28% | ABE | 3 | Nickname of the first US president to be assassinated |
| 28% | URANUS | 6 | First planet discovered with the aid of a telescope |
| 27% | HAMMURABI | 9 | Babylonian King, said to be the first set of laws |
| 27% | AJANAOMIKING | 12 | "How to Get Away With Murder" actress whose first name is spelled the same forward and backward: 3 wds. |
| 27% | CONCUR | 6 | To agree with or be of the same opinion |
| 26% | SCHUMACHER | 10 | Retired German F1 racing driver who shares his first name with 31a, and according to Forbes is the fifth highest-paid athlete of all time |
| 26% | REM | 3 | Georgia band considered to be one of the first alternative rock groups |
| 26% | PELOSI | 6 | First woman to be Speaker of the House |
| 26% | RIGA | 4 | European capital said to be the site of the first decorated Christmas tree |
| 26% | MEMORIES | 8 | First word of the Barbra Streisand song "The Way We Were" |
| 26% | INKIND | 6 | Fair way to be repaid, as with goods of the same sort: 2 wds. |
| 26% | THEONION | 8 | Satirical outlet with the headline "Will Shortz Frustrated That Police Yet to Crack Taunting Puzzles Revealing Locations of 40 Years of Murder Victims" |
| 26% | JANETRENO | 9 | First woman to serve as attorney general of the US: 2 wds. |
| 26% | BIBLE | 5 | With 4-Down, much of the Southeast U.S. is in it |
| 26% | SPEAKOFTHEDEVIL | 15 | "We were just talking about you!" and a hint to the first words of the answers to the starred clues |
| 26% | RICHARD | 7 | ___ Rodgers, composer with works like "Oklahoma!' and "The Sound of Music" who was the first person to win the EGOT |
| 26% | SHH | 3 | [Some of us are trying to watch the movie here!] |
| 26% | BONO | 4 | First musician to be a ''Time'' Person of the Year |
| 26% | PROTO | 5 | Prefix with "type" to mean the first model of something |
| 25% | ELENA | 5 | First name of the most recent woman appointed to the US Supreme Court |
| 25% | JET | 3 | The Lippisch Ente was the first one of these to fly, in 1928 |
| 25% | ANAGRAM | 7 | The first half of each starred clue, with respect to its second half |
| 25% | REAGAN | 6 | First U.S. president with a star on the Hollywood Walk of Fame |