| 100% | YOSEMITESAM | 11 | He first appeared in the cartoon "Hare Trigger" |
| 61% | ABE | 3 | "Simpsons" character who first appeared in the cartoon "Grampa and the Kids" |
| 54% | DAFFY | 5 | Cartoon duck who first appeared in the 1937 short "Porky's Duck Hunt" |
| 50% | WASP | 4 | Insect that first appeared in the Jurassic era |
| 48% | ELMO | 4 | He first appeared in 1980 during a song called "We Are All Monsters" |
| 48% | APU | 3 | Shopkeeper who first appears in the "Simpsons" episode "The Telltale Head" |
| 48% | BILLY | 5 | Speedy British comic character who first appeared in The Beano in 1964 |
| 47% | ABE | 3 | Animated character who first appeared in the Simpsons short "Grandpa and the Kids" |
| 47% | NANCYDREW | 9 | Character who first appeared in "The Secret of the Old Clock" |
| 47% | XENA | 4 | Character who first appeared in "Hercules: The Legendary Journeys" |
| 46% | ELMO | 4 | Red Muppet who first appeared in the "Sesame Street" song "We Are All Monsters" |
| 46% | GEORGESMILEY | 12 | Fictional spy who first appeared in "Call for the Dead" |
| 46% | BETTYBOOP | 9 | Cartoon flapper first appearing in 1930 |
| 46% | KERMITTHEFROG | 13 | Muppet whose balloon first appeared in the 1977 Macy's Thanksgiving Day Parade: 3 wds. |
| 46% | CHAN | 4 | Charlie —, detective creation of Earl Biggers who first appeared in The House Without a Key |
| 45% | THESISSTATEMENT | 15 | Sentence that often appears in the first paragraph of an essay |
| 45% | BARTSIMPSON | 11 | Bratty toon whose balloon first appeared in the 1990 Macy's Thanksgiving Day Parade: 2 wds. |
| 45% | MICKEYMOUSE | 11 | Disney character whose balloon first appeared in the 1934 Macy's Thanksgiving Day Parade: 2 wds. |
| 45% | OONA | 4 | Actress Chaplin who appeared in the first season of "Game of Thrones" |
| 45% | HANSOLO | 7 | In the original cut of Star Wars, he shot first |
| 43% | PADME | 5 | Queen who first appears in “The Phantom Menace” |
| 43% | OPED | 4 | The first one in The New York Times appeared in 1970 |
| 43% | YODA | 4 | Alien who first appears in "The Empire Strikes Back" |
| 42% | THOR | 4 | Superhero with a hammer who appeared in the first issue of the comic book "The Avengers" |
| 42% | ACTI | 4 | When the witches first appear in "Macbeth" |
| 42% | HUCKLEBERRY | 11 | ___ Finn, a fictional character who first appeared in 51a and is a friend of the protagonist |
| 42% | THEEXCHANGE | 11 | 2023 novel by 41-Across that features lawyer Mitch McDeere, who first appeared in the 1991 novel "The Firm" (2 wds.) |
| 42% | GOOFY | 5 | Walt Disney character originally called Dippy Dawg who first appeared in 1932 animated cartoon Mickey's Revue |
| 42% | DOCSAVAGE | 9 | Fictional character created by Lester Dent who first appeared in 1933 pulp novel The Man of Bronze |