| 100% | JENNINGS | 8 | He hosted the first "Jeopardy!" in the post-Trebek era |
| 47% | YOSEMITESAM | 11 | He first appeared in the cartoon "Hare Trigger" |
| 46% | ORR | 3 | He signed the first million-dollar contract in the NHL |
| 46% | WASP | 4 | Insect that first appeared in the Jurassic era |
| 46% | GREYCUP | 7 | Toronto hosted the first __ football game in 1909 |
| 46% | ALEX | 4 | ___ Trebek, "Jeopardy!" host who guest starred on an episode in the '80s sitcom "Cheers" |
| 46% | ELMO | 4 | He became the first puppet to testify before Congress in 2002 |
| 45% | URUGUAY | 7 | Country hosting the first FIFA World Cup in 1930 |
| 44% | ORR | 3 | He was the first hockey player to have 100 assists in one season |
| 44% | FRANCE | 6 | Host country of the first Winter Olympics in 1924 |
| 44% | MANTOVANI | 9 | Annunzio Paolo —, Venice-born arranger-conductor popular in the post-war era in Britain |
| 44% | HANSOLO | 7 | In the original cut of Star Wars, he shot first |
| 43% | ONTHELINE | 9 | In jeopardy ... and where the first words of the answers to starred clues can be found |
| 42% | VENUSWILLIAMS | 13 | First Black woman ranked No. 1 singles player in the Open Era |
| 42% | LASORDA | 7 | He managed the U.S. to its first Olympic gold in baseball |
| 42% | ELMO | 4 | He hosted HBO Max's "Not-Too-Late Show" in the early 2020s |
| 42% | MEL | 3 | Allen who was the first host of "This Week in Baseball" |
| 41% | FRANTARKENTON | 13 | Pro Football Hall of Fame quarterback who was the first pro athlete to host "Saturday Night Live," in 1977, two years after he was named the NFL MVP (2 wds.) |
| 41% | EVE | 3 | The first woman in the Bible |
| 41% | BRITISH | 7 | The first B in the BBC |
| 40% | HYDROGEN | 8 | The first element in the periodic table |
| 40% | HOBOKEN | 7 | City that hosted what some say was the first organized baseball match, in 1846 |
| 40% | KENJENNINGS | 11 | "Jeopardy!" host who grew up in the Mormon church: 2 wds. |
| 39% | REDDRAGON | 9 | The first novel in the Hannibal Lecter saga |
| 39% | COMPLETE | 8 | The first C in the medical term CBC |
| 39% | POSITIVE | 8 | The first P in the medical abbreviation CPAP |
| 39% | OTOE | 4 | The first O in the URL omtribe.org
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| 39% | VENUSWILLIAMS | 13 | First African-American woman to hold the world #1 ranking in tennis's Open era: 2 wds. |
| 39% | XRAY | 4 | Discovery of Wilhelm Roentgen, which earned him the first Nobel Prize in Physics in 1901 |
| 39% | SANTO | 5 | The first word in the Dominican Republic's capital |