| 100% | SACAJAWEA | 9 | Her face began to circulate in 2000 |
| 39% | SACAGAWEADOLLAR | 15 | It first circulated in 2000 |
| 38% | OPENUPTO | 8 | Begin to confide in |
| 38% | MAGGIENELSON | 12 | Her 2009 book opens, “Suppose I were to begin by saying I had fallen in love with a color” |
| 37% | THAW | 4 | Begin to melt in warm weather |
| 37% | UNZIP | 5 | Begin to remove, in a way |
| 35% | VENTILATE | 9 | Allow air to circulate; let fresh air in |
| 33% | DACAPO | 6 | In music, instruction to repeat from the beginning |
| 33% | LABEFANA | 8 | She delivers gifts to kids in Italy on Epiphany |
| 33% | JLO | 3 | "Maid in Manhattan" actress, to her fans |
| 32% | TIVO | 4 | Way to watch shows beginning in 1999 |
| 32% | INITIATE | 8 | Establish, set in motion; cause to begin |
| 32% | ISABELLA | 8 | She tries to save her bro in Measure for Measure |
| 32% | HRC | 3 | She lost to D.J.T. in the '16 election |
| 32% | MATILDA | 7 | She stands up to Trunchbull in Roald Dahl's book |
| 32% | ARMAS | 5 | She was Paloma in No Time to Die, Ana de __ |
| 32% | MARIA | 5 | Tony sings to her in "West Side Story" |
| 32% | BACK | 4 | Begin to parallel park, with "in" |
| 31% | KARATE | 6 | Sport whose belt levels, from beginning to advanced, appear in the starred answers |
| 31% | BLOODY | 6 | To be hit in the face may cause this secreting nose |
| 31% | MARIA | 5 | She's a problem that needs to be solved, in song |
| 31% | CDC | 3 | Org. that began recommending face masks in April, 2020 |
| 31% | ILOST | 5 | "___ my heart to her" (fell in love): 2 wds. |
| 31% | KEIRA | 5 | ___ Knightley, "Pirates of the Caribbean" actress who learned to play the guitar for her role in "Begin Again" |
| 31% | KATIE | 5 | She went to Haiti, in a Cole Porter song |
| 31% | USHERETTE | 9 | She guides you to a seat in a cinema |
| 31% | FANTINE | 7 | She turns to prostitution in Les Miserables |
| 31% | ACELA | 5 | Track speedster beginning in 2000 |
| 31% | ZZOOOOMM | 8 | Auto slogan beginning in 2000 |
| 31% | ANA | 3 | She acted opposite Daniel in “No Time to Die” and “Knives Out” |