| 100% | GUITARHERO | 10 | Hit video game series featuring "hammer-ons" |
| 65% | HALO | 4 | Video game series featuring Master Chief |
| 64% | HALO | 4 | Video game series featuring the alien Covenant |
| 64% | TEKKEN | 6 | Video game series featuring Kuma the bear |
| 64% | HALO | 4 | Video game series featuring supersoldier Master Chief |
| 64% | GUITARHERO | 10 | Hit video game series launched in 2005 |
| 62% | APE | 3 | ___ Escape (rhyming video game series featuring intelligent primates) |
| 61% | SIMS | 4 | Virtual people in a hit video game series |
| 58% | HILL | 4 | Hit 2006 horror film based on a video game series |
| 56% | DDR | 3 | Music video game series in which players step on arrows (Abbr.) |
| 55% | ANIMALCROSSING | 14 | Video game series whose 2020 "New Horizons" game was a big hit: 2 wds. |
| 55% | HERO | 4 | Guitar ___ (hit video game series) |
| 55% | EVIL | 4 | "Resident ___," horror video game series that features zombies and other mutant creations |
| 54% | GRAN | 4 | "___ Turismo," racing video game series published by Sony that features real-world automobiles |
| 54% | JUST | 4 | "___ Dance" video game series by Ubisoft first released on Wii Nintendo in 2009 |
| 52% | MAY | 3 | "Devil ___ Cry" (video game series featuring the demon hunter Dante) |
| 50% | MADDENNFL | 9 | Video game franchise that featured 15-Across on the cover of the 2011 version: 2 wds. |
| 50% | TEAM | 4 | "___ Fortress 2," comic series based on the video game series that features mercenaries |
| 49% | SIMCITY | 7 | Video game series since 1989 |
| 49% | GUITARHERO | 10 | Video game series with strumming |
| 48% | GODOFWAR | 8 | Kratos video-game series based on Greek mythology |
| 48% | TOMB | 4 | "___ Raider," comic book series based on the video game that features Lara Croft |
| 48% | ANGRY | 5 | "___ Birds," video game series |
| 48% | BIRDS | 5 | "Angry ___," video game series |
| 48% | MAGIC | 5 | 1984 hit by the Cars whose video featured Ric Ocasek standing on water |
| 47% | GODOFWAR | 8 | Game series featuring Kratos as the protagonist |
| 47% | NEED | 4 | "___ for Speed," video game series |
| 47% | HERO | 4 | Guitar ___ (discontinued video game series) |
| 47% | HALO | 4 | Popular Xbox video game series |
| 47% | ACE | 3 | Adventure video game series "___ Attorney" |