| 100% | ELSIE | 5 | Holmes novel "____ Venner" |
| 58% | PERCENTSOLUTION | 15 | ← Sherlock Holmes novel, with "The" |
| 57% | ELSIE | 5 | Holmes's Miss Venner |
| 55% | HOUND | 5 | “The ___ of the Baskervilles” (Sherlock Holmes novel) |
| 55% | HOUND | 5 | "The ___ of the Baskervilles" (Sherlock Holmes novel) |
| 52% | VALLEY | 6 | __ of Fear, the last of the Sherlock Holmes novels |
| 52% | SLEB | 4 | 2002 novel by Andrew Holmes |
| 50% | SOLO | 4 | "Flying ___" (2022 novel by Linda Holmes) |
| 50% | ENOLA | 5 | Detective Holmes of Nancy Springer novels |
| 49% | STUDY | 5 | "A ___ in Scarlet" (first Sherlock Holmes novel by Arthur Conan Doyle) |
| 49% | FOUR | 4 | "The Sign of the ___," Sherlock Holmes novel by Arthur Conan Doyle |
| 49% | BASKERVILLES | 12 | "The Hound of the ___," Sherlock Holmes novel by Arthur Conan Doyle |
| 49% | OVER | 4 | "Evvie Drake Starts __": novel by Linda Holmes |
| 48% | ELSIE | 5 | Holmes's "___Venner" |
| 48% | HOUND | 5 | "The ___ of the Baskervilles," iconic Sherlock Holmes novel with seemingly supernatural elements |
| 46% | POISOND | 7 | Cause of death in the Sherlock Holmes novel "The Sign of the Four" |
| 44% | SIGNOFFOUR | 10 | The —, 1890 novel by Arthur Conan Doyle featuring Sherlock Holmes |
| 44% | ANNO | 4 | "___ Dracula," alternate history novel where Sherlock Holmes is a character |
| 43% | ENOLA | 5 | Sherlock Holmes's younger sister in a series of YA novels |
| 42% | IRENE | 5 | Adler who is the protagonist of the novel “Good Night, Mr. Holmes” |
| 41% | ASTUDYIN | 8 | & 16D First of four Sherlock Holmes novels by Arthur Conan Doyle, published in book form in 1888 |
| 36% | ELSIE | 5 | Oliver Wendell Holmes's "___Venner" |
| 35% | NEW | 3 | Novel |
| 35% | UNUSUAL | 7 | Novel |
| 35% | NEWFANGLED | 10 | Novel |
| 35% | FRESH | 5 | Novel |
| 35% | BOOK | 4 | Novel |
| 35% | ORIGINAL | 8 | Novel |
| 34% | BAKER | 5 | 221B ___ Street, home to Sherlock Holmes and John Watson in Arthur Conan Doyle's period novel series |
| 34% | MAN | 3 | "The ___ from U.N.C.L.E." novel that features a cameo by a retired Sherlock Holmes |