| 100% | ARSENIOHALL | 11 | Host of a 1990s late-night talk show that was briefly revived 20 years later |
| 41% | RUPAUL | 6 | Host of a self-titled 1990s talk show |
| 40% | ELLENDEGENERES | 14 | Talk show host and star of a 1990s ABC sitcom, whose title was her first name: 2 wds. |
| 38% | JIMMYKIMMEL | 11 | Late-night talk show host who hosts the prime-time game show "Who Wants to Be a Millionaire": 2 wds. |
| 38% | JOANRIVERS | 10 | Comedian who was the first woman to host a late-night talk show on a major network: 2 wds. |
| 37% | TONYS | 5 | Awards show that was hosted three years in a row by Ariana DeBose |
| 36% | JOAN | 4 | ___ Rivers, comedian and actress who was the first woman to host a late-night network TV talk show |
| 36% | THELATESHOW | 11 | Previously hosted by David Letterman, and now starring Stephen Colbert, CBS talk-show that was a fierce competitor of 40-Across: 3 wds. |
| 36% | LIVE | 4 | "Saturday Night ___," American late night variety show that had LeBron James as the host of the season 33 premiere |
| 35% | SETHMEYERS | 10 | NBC "Late Night" host whose show was nominated for a 2020 Writers Guild Award for Comedy/Variety Talk Series (2 wds.) |
| 35% | JAMESCORDEN | 11 | English late night show host who was the co-creator of BBC's Gavin & Stacey: 2 wds. |
| 35% | WILDKINGDOM | 11 | Nature show on Animal Planet, a revival of a 1963-1988 show that was hosted by Marlin Perkins: 2 wds. |
| 35% | DESK | 4 | Piece of furniture on a late-night talk show |
| 35% | STEPHENCOLBERT | 14 | Host of "The Late Show" who was once a correspondent on "The Daily Show": 2 wds. |
| 35% | JIMMYKIMMEL | 11 | American late night show host who was the co-host of Comedy Central's "The Man Show": 2 wds. |
| 34% | INTERVIEW | 9 | Part of a late-night talk show |
| 34% | SUGAR | 5 | "___ Rush Christmas," holiday-themed season of a reality baking show that is hosted by Hunter March |
| 34% | JAMES | 5 | British comedian Corden who hosts a late-night talk show on CBS |
| 34% | SARAHSILVERMAN | 14 | Humorous and heavy metal component of Hulu's late-night talk show that ran in 2017-18 |
| 33% | RONREAGAN | 9 | Host of a short-lived talk show |
| 33% | RISEANDSHINE | 12 | 43-Across novel about a morning talk show host who is fired because of an on-air gaffe (3 wds.) |
| 33% | CHELSEA | 7 | With 33-Across, comedian who hosted a late-night talk show on E! from 2007-2014 |
| 33% | THEDAILYSHOW | 12 | News satire and late-night talk show, for which Steve Carell was a correspondent: 3 wds. |
| 32% | OVETT | 5 | British Middle-distance runner Steve ___, who in 1987 had bronze statue erected in Brighton, UK that was stolen 20 years later |
| 32% | ELMO | 4 | Nonhuman host of a talk show on HBO Max |
| 32% | JOHNOLIVER | 10 | Host of "Last Week Tonight" who was once a correspondent on "The Daily Show": 2 wds. |
| 32% | OPRAH | 5 | Host of a daytime show that had an annual "Favorite Things" segment |
| 32% | BENSTILLER | 10 | Host of a 1990s sketch comedy show who starred in and wrote both "Zoolander" movies (2 wds.) |
| 31% | ROLONDA | 7 | Watts who hosted a 1990s talk show |
| 31% | ARSENIO | 7 | Hall who hosted a 1990s talk show |