| 100% | MIR | 3 | Humans last lived there in 2000 |
| 44% | VERONA | 6 | Two gentlemen lived there in Shakespeare comedy |
| 40% | ZION | 4 | Last human city in "The Matrix" |
| 39% | PREGNANCY | 9 | Lasts nine months in humans |
| 38% | EDEN | 4 | First place humans lived in the Bible |
| 38% | OXYGEN | 6 | Element in air humans breathe to live |
| 37% | MIR | 3 | It was last inhabited in 2000 |
| 37% | ADAM | 4 | First human who lived in Eden |
| 36% | ZION | 4 | Last human city on Earth, in "The Matrix" |
| 36% | NIT | 3 | Bug that likes to live in clean human hair |
| 35% | NOOSE | 5 | Last method of death in Agatha Christie's "And Then There Were None" |
| 35% | NOOSE | 5 | Last method of death in Agatha Christie’s “And Then There Were None” |
| 34% | NYET | 4 | Possible reply to "Was there interference in the last American presidential election?" |
| 32% | EWER | 4 | Some people suspect there are crocodiles living in the New York City s___s |
| 32% | ACCEPTIT | 8 | “There’s no use living in denial” |
| 32% | ALCOA | 5 | It acquired Reynolds Metals in 2000 |
| 32% | CSI | 3 | Hit CBS series starting in 2000 |
| 32% | CSI | 3 | CBS drama that debuted in 2000 |
| 32% | PEACESUMMIT | 11 | President Clinton hosted one in 2000 |
| 32% | TATEMODERN | 10 | London museum that opened in 2000 |
| 32% | GORE | 4 | He ran against Bush in 2000 |
| 32% | JOSEPHLIEBERMAN | 15 | Gore's running mate in 2000 |
| 32% | ALLABOUTLOVE | 12 | bell hooks book published in 2000 |
| 32% | CAINE | 5 | Michael who was knighted in 2000 |
| 32% | CSI | 3 | CBS procedural franchise launched in 2000 |
| 32% | BAD | 3 | Song James Bay performed live on "The Late Show with Stephen Colbert" in May 2019 |
| 31% | NADER | 5 | Also-ran in 2000 |
| 31% | GILMOREGIRLS | 12 | Quirky 2000-2007 drama about a mother and daughter living in Stars Hollow, Connecticut: 2 wds. |
| 31% | OPPONENTS | 9 | Bush and Gore, in 2000 |
| 31% | STCROIX | 7 | Crucians live there |