| 100% | EASEL | 5 | I and 28a are an artist's best friends. I hold the canvas. Who am I? |
| 65% | PAINT | 5 | I and 38d are an artist's best friends. I add color to their art. Who am I? |
| 45% | CHALK | 5 | I am a teacher's best friend. I help them write on the blackboard. Who am I? |
| 44% | ROD | 3 | I am a fisherman's best friend. I help them pull the fish once it's hooked. Who am I? |
| 42% | RACHEL | 6 | I am Phoebe's friend from "Friends" and I gave the world an iconic hairstyle |
| 41% | CHARLEYPRIDE | 12 | "Kiss an Angel Good Mornin'" singer who was the first Black country artist to cohost the CMA Awards (1975) and the ACM Awards (1980): 2 wds. |
| 39% | CAMERA | 6 | I am a photographer's best friend. I help them capture every memory. Who am I? |
| 39% | WOLF | 4 | I'm an "Arctic" canine and the cold never bothered me anyway. Who am I? |
| 39% | GEORGECOSTANZA | 14 | Character who is Jerry's best friend since high school and is played by Jason Alexander on the show "Seinfeld": 2 wds. |
| 38% | MADONNA | 7 | Singer from the U.S. who is known as the "Queen of Pop" and is the best-selling female artist of all time |
| 38% | CHARLOTTESWEB | 13 | Children's classic with the line "It is not often that someone comes along who is a true friend and a good writer" |
| 38% | BRUSH | 5 | I am a hairstylist's best friend. I help them comb out stubborn knots. Who am I? |
| 38% | NERO | 4 | Roman emperor who said before dying "What an artist the world is losing in me!" |
| 38% | NERO | 4 | Roman emperor who said before dying, "What an artist the world is losing in me!" |
| 38% | KNIFE | 5 | I am a chef's best friend. I help chop veggies for a good stew. Who am I? |
| 38% | SAW | 3 | I am a woodworker's best friend, I help them cut through planks of wood. Who am I? |
| 37% | ELVIS | 5 | Presley, one of the best-selling American artists who was called "The King of Rock and Roll" |
| 37% | LANDONDONOVAN | 13 | U.S. soccer player who holds multiple records in the Major League Soccer, and was Best Young Player in the 2002 FIFA World Cup: 2 wds. |
| 37% | MAKEUP | 6 | I am a type of "artist" who can work with prosthetics and special effects on an actor's face. Who am I? |
| 37% | GRACE | 5 | Will's best friend on an American sitcom starring Eric McCormack and Debra Messing |
| 37% | CHARLOTTESWEB | 13 | Children's classic by 50-Across with the line, "It is not often that someone comes along who is a true friend and a good writer" (2 wds.) |
| 36% | DOG | 3 | I'm a loyal canine known to be "man's best friend." Who am I? |
| 36% | MEGHANTRAINOR | 13 | "All About the Bass" And "Lips Are Movin" singer who won the 2016 Best New Artist Grammy Award (2 wds.) |
| 36% | MITSKI | 6 | Singer who wrote the lyric "Give me one good movie kiss and I'll be alright" |
| 36% | NED | 3 | Leeds who is Spider-Man's best friend in the MCU movies |
| 35% | ROONEY | 6 | Sally who wrote “Beautiful World, Where Are You,” which features e-mails between an acclaimed novelist and her best friend (September, 2021) |
| 35% | SERENAWILLIAMS | 14 | American tennis player who holds the most Grand Slam titles and has been an active participant in charity, fashion etc.: 2 wds. |
| 35% | CRICKET | 7 | I have thin wings and long legs. I chirp only in the night. Who am I? |
| 35% | SHERYLCROW | 10 | "All I Wanna Do" singer who won the Best New Artist and Record of the Year Grammys in 1995: 2 wds. |
| 35% | BERT | 4 | Ernie's best friend on "Sesame Street" for whom Ernie dedicated the song "That's What Friends Are For" |