| 100% | HELEN | 5 | I was the first deaf-blind person to earn a B.A. degree and I campaigned for women's rights |
| 49% | SUSAN | 5 | ___ La Flesche Picotte, doctor and reformer who was the first Native American woman to earn a medical degree |
| 42% | KELLER | 6 | Helen, first deaf-blind person to earn a BA degree |
| 41% | BLACKWELL | 9 | Elizabeth ___, British physician who was the first woman to earn a medical degree in the US |
| 41% | HELEN | 5 | ___ Keller, first deaf and blind person to earn a Bachelor of Arts |
| 40% | LEE | 3 | Rebecca ___ Crumpler, physician who was the first African-American woman in the US to earn a medical degree |
| 40% | AMY | 3 | I was known for my beehive hairdo and I was the first British woman to win five Grammys |
| 38% | DOMEE | 5 | Shi who was the first woman to have the sole director’s credit on a Pixar feature, for “Turning Red” |
| 37% | EDITHWHARTON | 12 | 13-Across and 25-Across writer who was the first woman to win a Pulitzer Prize in Literature, for her 1920 novel "The Age of Innocence" (2 wds.) |
| 36% | HARRIETQUIMBY | 13 | First woman to earn a pilot's license in the United States and the first woman to fly across the English Channel (2 wds.) |
| 36% | EDITH | 5 | Wharton who was the first woman to win a Pulitzer Prize for fiction |
| 36% | TONIMORRISON | 12 | "Beloved" author who died August 5, and who was the first African-American woman to win a Nobel Prize: 2 wds. |
| 36% | ANNE | 4 | Sci-fi writer McCaffrey, who was the first woman to win a Hugo for fiction |
| 35% | JACKIESTILES | 12 | 2016 Women's Basketball Hall of Fame inductee who was the first Division I player to score over 1,000 points in a season: 2 wds. |
| 35% | RONALDREAGAN | 12 | U.S. president who was the first born in Illinois, the first to have been divorced, and the first to nominate a woman to the Supreme Court (2 wds.) |
| 35% | ANGELA | 6 | Bassett who was the first person to be nominated for an Oscar for acting in a Marvel movie |
| 35% | VVEBDUBOIS | 10 | Historian, essayist and civil rights leader who was the first African American to receive a doctorate at Harvard |
| 35% | JOAN | 4 | ___ Rivers, comedian and actress who was the first woman to host a late-night network TV talk show |
| 34% | FREEMAN | 7 | Cathy ___, sprinter who was the first Australian indigenous person to become a Commonwealth Games gold medalist |
| 34% | GRETATHUNBERG | 13 | First Swedish woman and first person born in the 21st century to be named "Time" magazine's Person of the Year (2 wds.) |
| 34% | MARIE | 5 | ___ Maynard Daly, the first African American woman to earn a Ph.D. in chemistry |
| 34% | CAROLEKING | 10 | "You've Got a Friend" singer/pianist who was the first woman to win a Grammy for Song of the Year (2 wds.) |
| 33% | OBERLIN | 7 | Ohio college that was the first in the U.S. to award degrees to women |
| 33% | ALTHEA | 6 | Gibson who was the first person of color to win a tennis Grand Slam event |
| 33% | WARRENHARDING | 13 | U.S. president who was the first to be elected on his birthday, the first born after the Civil War, and the first elected after women gained the right to vote (2 wds.) |
| 33% | HELEN | 5 | ___ Keller, first deafblind person to earn a Bachelor of Arts degree |
| 33% | ALTHEAGIBSON | 12 | Tennis great who was the first person of color to win a Wimbledon championship (2 wds.) |
| 33% | KAMALAHARRIS | 12 | Former California senator who is the first woman and first person of color to be inaugurated as vice president of the United States (2 wds.) |
| 33% | GWENJORGENSEN | 13 | American distance runner and two-time ITU World Champion who was the first to win a triathlon gold for USA in the Olympics: 2 wds. |
| 33% | CARRIERPIGEONNAMEDGIJOE | 23 | The first non-British to receive Britain's Dickin Medal for Gallantry was a _____ |