| 100% | MARIO | 5 | Iconic video game character in overalls |
| 62% | LUIGI | 5 | Video game character in a green hat |
| 62% | SIM | 3 | Video game character in a virtual city |
| 61% | SONIC | 5 | Video game character in a hit 2020 film |
| 61% | MARIO | 5 | Nintendo's iconic video game character |
| 56% | PACMAN | 6 | Video game character who nibbles up dots in a maze: Hyph. |
| 55% | SIM | 3 | Character in a city-building video game |
| 55% | MARIO | 5 | Video game character repeatedly told "but our princess is in another castle!" |
| 55% | SIM | 3 | Character in an early city-building video game |
| 54% | FORTNITE | 8 | Video game with Thanos as guest character in 2018 |
| 54% | NPC | 3 | Background character in a video game, briefly |
| 54% | MARIO | 5 | Overalls-clad video game character |
| 52% | SIMS | 4 | Characters in the video game designer Will Wright's "virtual dollhouse" |
| 52% | FIXITFELIXJR | 12 | Video game in which 20-Across's title character appears: 3 wds. |
| 52% | ALIEN | 5 | Many a character in the "Star Control" video game series |
| 51% | MARIO | 5 | First video game character to be honored with a figure in the Hollywood Wax Museum |
| 51% | SONIC | 5 | First video game character to have a balloon in the Macy's Thanksgiving Day Parade |
| 51% | DRMARIO | 7 | Video game in which a Nintendo character tosses capsules into a medicinal bottle |
| 50% | MARIO | 5 | Main character in the best-selling video game franchise of all time |
| 50% | SIMS | 4 | Eponymous characters in a video game with an Eco Lifestyle expansion pack |
| 48% | KONG | 4 | Donkey ___, series of video games first released in 1981 and which has a gorilla character |
| 48% | LARA | 4 | Video game character Croft |
| 47% | MAIN | 4 | One's primary character, in video game lingo |
| 47% | MARIO | 5 | Video-game character who wears overalls and a red hat |
| 46% | ALISONBRIE | 10 | "Community" actress who voices characters in the video games "Lego Dimensions" and "Marvel Avengers Academy" (2 wds.) |
| 46% | ZELDA | 5 | Video game character rescued by Link |
| 46% | MARIO | 5 | Video game character who battles Bowser |
| 46% | HEDGEHOG | 8 | Video game character Sonic is one |
| 46% | SIM | 3 | Video game character that might WooHoo |
| 46% | MARIO | 5 | "Super" video game character |