| 100% | OMAR | 4 | Ilhan ___, one of the first two Muslim women elected to Congress |
| 94% | OMAR | 4 | Minnesotan Ilhan who is one of the first two Muslim women elected to Congress |
| 52% | WASHINGTON | 10 | One of the first two states to permit marijuana for recreational use |
| 52% | COLORADO | 8 | One of the first two states to permit marijuana for recreational use |
| 49% | TENZINGNORGAY | 13 | Sherpa who was one of the first two people to conquer Mount Everest: 2 wds. |
| 48% | EDMUNDHILLARY | 13 | New Zealand mountaineer who was one of the first two people to conquer Mount Everest: 2 wds. |
| 46% | SHIRLEYCHISHOLM | 15 | First Black woman elected to the U.S. Congress |
| 46% | ANGELS | 6 | One of the first two MLB expansion teams |
| 44% | BUFFALOBILL | 11 | One of the first two ''American superstars,'' per 34 Across' book |
| 44% | ANNIEOAKLEY | 11 | One of the first two ''American superstars,'' per 34 Across' book |
| 44% | RANKIN | 6 | Jeannette who was the first woman elected to Congress (1916) |
| 44% | CHATROOM | 8 | One of the first ways to communicate online |
| 44% | SARAHPALIN | 10 | In 2006, she became the first woman to be elected governor of Alaska: 2 wds. |
| 43% | OMAR | 4 | Ilhan, the first Somali-American elected to Congress |
| 43% | YEA | 3 | One of the first to raise a hand, usually |
| 43% | JONASSALK | 9 | One of the first to develop a polio vaccination |
| 43% | ARP | 3 | One of the first artists to incorporate random chance |
| 43% | BAEZ | 4 | One of the first to record Dylan's songs |
| 43% | SUSANAMARTINEZ | 14 | In 2010, she became the first woman to be elected governor of New Mexico: 2 wds. |
| 43% | NIKKIHALEY | 10 | In 2010, she became the first woman to be elected governor of South Carolina: 2 wds. |
| 43% | TWENTIETHCENTURY | 16 | One of the first Buicks to roll off the line? |
| 42% | OPHELIA | 7 | One of the two women in "Hamlet" |
| 42% | HOWE | 4 | Julia ___, first woman elected to the American Academy of Arts and Letters |
| 41% | ELLISON | 7 | Keith who was the first Muslim elected to Congress |
| 41% | SHIRLEYCHISHOLM | 15 | First black woman elected to Congress, 1968 |
| 41% | ICET | 4 | One of the first musicians to have an "explicit content" sticker on an album |
| 41% | NAT | 3 | ___ "Sweetwater" Clifton, one of the first Black players to play in the NBA |
| 41% | THISISLANDEARTH | 15 | 1955 sci-fi film that was one of the first to use Technicolor |
| 40% | HAROLD | 6 | One of the two film stoners who "go to White Castle" |
| 40% | MALIK | 5 | Surname of the first member to leave One Direction |