| 100% | HOPS | 4 | Imparter of bitterness to beer |
| 53% | HOPS | 4 | Plants that add bitterness to beer |
| 50% | OAK | 3 | Imparter of flavor to cabernet sauvignon wines |
| 45% | MOE | 3 | Server of Duff Beer to Homer |
| 44% | MOE | 3 | Server of Duff Beer to Homer Simpson |
| 44% | EDIFY | 5 | Impart pearls of wisdom to |
| 44% | BUD | 3 | Beer that claims to be "The King of Beers," familiarly |
| 43% | AIRPORTBAR | 10 | Apt place to order a flight of beer? |
| 43% | BARLEY | 6 | Member of the grass family, used to make beer |
| 43% | ALE | 3 | Type of beer that dates back to medieval England |
| 42% | FEST | 4 | Suffix with "Oktober" to mean the annual celebration of beer |
| 42% | IPA | 3 | Style of craft beer that tends to be bitter: Abbr. |
| 41% | IPA | 3 | Type of beer that tends to taste bitter from hops: Abbr. |
| 39% | KEG | 3 | Stainless steel container that can hold up to 15.5 gallons of beer |
| 38% | HOPS | 4 | They add flavor to beer |
| 38% | CHEWABLE | 8 | Adjective sometimes used to describe the extra thick quality of Guinness Extra Stout beer |
| 38% | LIKABLE | 7 | Having the qualities of someone you might want to get a beer with, say |
| 38% | MICROBREW | 9 | Craft beer . . . and a hint to the contents of four squares in this puzzle |
| 38% | YOLKS | 5 | Imparters of richness |
| 38% | ESTER | 5 | Imparter of fruity overtones |
| 37% | ESTER | 5 | Imparter of a fruity flavor |
| 37% | STOUT | 5 | Kind of beer ... or a multi-word hint to 18-, 22-, 37-, 51- and 57-Across |
| 36% | CIDER | 5 | Gluten-free alternative to beer |
| 36% | HOPS | 4 | Sources of bitterness |
| 36% | BASICINGREDIENT | 15 | Water, to beer |
| 36% | MSG | 3 | Imparter of umami taste, in brief |
| 35% | NEVER | 5 | "___ succumb to the temptation of bitterness": MLK |
| 35% | BREWPUB | 7 | Place to get a beer |
| 35% | KEG | 3 | Small barrel to dispense beer |
| 34% | MOE | 3 | Cartoon seller of Duff Beer |