| 100% | RADIO | 5 | In 1922, Warren G. Harding became the first U.S. president to be broadcast over this |
| 46% | DOG | 3 | President Trump is the first president in over 100 years not to have one of these |
| 46% | WARRENGHARDING | 14 | U.S. president who, in 1922, became the first president to have his voice transmitted on the radio (3 wds.) |
| 43% | USN | 3 | JFK was the first president to have served in this branch of the US Armed Forces |
| 39% | CALVINCOOLIDGE | 14 | US vice president who became president upon the death of Warren Harding in 1923: 2 wds. |
| 38% | RONALDREAGAN | 12 | U.S. president who was the first born in Illinois, the first to have been divorced, and the first to nominate a woman to the Supreme Court (2 wds.) |
| 37% | GAMALIEL | 8 | The G in President Warren G Harding's name |
| 37% | ABE | 3 | Nickname of the first US president to be assassinated |
| 37% | PALMSPRINGS | 11 | California city that, in 2018, became the first U.S. city to have an all-L.G.B.T. city council |
| 36% | JEEP | 4 | The 2020 Gladiator is this brand's first pick-up truck in over 25 years |
| 36% | LAIKA | 5 | Dog who became the first living being to orbit the Earth in 1957 |
| 36% | JAMESMADISON | 12 | U.S. president who was the first to have served in the House of Representatives, the first to have an inaugural ball, and the first to wear long pants instead of knee breeches (2 wds.) |
| 35% | IKE | 3 | Nickname of the first U.S. president born in 7-Down |
| 34% | BURR | 4 | First U.S. vice president not to become president |
| 34% | EIGHTIES | 8 | Ronald Reagan was the US president in this decade |
| 34% | GRANT | 5 | This US president was buried in the largest mausoleum in North America |
| 34% | TYLER | 5 | First U.S. vice president to ascend to the presidency |
| 34% | ORANGUTANS | 10 | In 2014 Argentina became the first country to recognize these primates' legal rights |
| 34% | SEP | 3 | Wm. H. Taft was the only U.S. president born in this month |
| 34% | OBERLIN | 7 | Ohio college that was the first in the U.S. to admit women |
| 34% | TOBACCO | 7 | Rolfe was the first to cultivate this in Virginia |
| 33% | JACKSON | 7 | First US President to be the target of an assassination attempt (which failed), on January 30, 1835 |
| 33% | ALABAMA | 7 | Montgomery's state that was the first US state to recognize Christmas as a holiday in 1836 |
| 33% | OBERLIN | 7 | Ohio college that was the first in the U.S. to award degrees to women |
| 33% | JOHN | 4 | In 1912, 24,587 new male babies in the US were given this first name |
| 33% | HAYES | 5 | First president to have a phone in the White House—its number was "1" (1877) |
| 33% | USA | 3 | This nation's athlete is the first figure skater to land eight quads in a competition |
| 33% | SARAHPALIN | 10 | In 2006, she became the first woman to be elected governor of Alaska: 2 wds. |
| 33% | SNOW | 4 | "It's the first ___ of the year! The holiday season is upon us! Look out for fun hidden themes throughout this month in DTC!" |
| 33% | HONDAACCORD | 11 | First car from a Japanese manufacturer to be made in the U.S. (1982) |