| 100% | DROSOPHILA | 10 | In its stock center, Cornell University maintains cultures of hundreds of species of this genus of flies |
| 26% | WILLHELM | 8 | Stock scream heard in hundreds of movies |
| 25% | SPECULATE | 9 | It can be risky to do this in the stock market |
| 25% | SOUP | 4 | You might put a lot of stock in it |
| 25% | KANSAS | 6 | The geographic center of the 48 states is in it |
| 25% | ANTE | 4 | It goes in the center of the table |
| 25% | NOSE | 4 | It's in the center of the face |
| 24% | GAS | 3 | Boston's Haymarket Square had its first of this type of lamp installed in 1828 |
| 24% | EYE | 3 | Crustaceans in the genus Cyclops have only one of this organ |
| 24% | 9PIN | 4 | It's in the back row, right of center |
| 24% | RAIN | 4 | It's summoned by Agwe, the god of water in "Once on This Island" |
| 24% | SENATOR | 7 | Every state in America has two of these representing it in DC |
| 24% | TONI | 4 | Braxton who released the single "Do It" in April of this year |
| 24% | LIMA | 4 | Its National University of San Marcos was founded in 1551 |
| 24% | IRIS | 4 | A pupil is in the center of it |
| 24% | SNOW | 4 | Balls of it are found in this puzzle |
| 24% | COMA | 4 | You're out of it when in this |
| 24% | SALMONELLA | 10 | Genus of bacteria occurring mainly in the gut, many species of which cause food poisoning |
| 24% | FLOCK | 5 | Gathering of 1-Down, like that found in the center of this puzzle |
| 24% | JET | 3 | The Lippisch Ente was the first one of these to fly, in 1928 |
| 23% | ERR | 3 | “Admittedly I ___ by undertaking / This in its present form” (opening of “The Changing Light at Sandover”) |
| 23% | SANDWICHSHOP | 12 | Its menu might include the ends of seven answers in this puzzle |
| 23% | ZODIAC | 6 | All 12 of its symbols are featured in this puzzle |
| 23% | NUCLEARFAMILY | 13 | Members of this can be found in the centers of 17-, 24-, 51- and 60-Across |
| 23% | EARTH | 5 | "Journey to the Center of the ___," Jules Verne novel that features our planet in its title |
| 23% | TIBER | 5 | Legend has it that Rome was founded in 753 BC on the banks of this river |
| 22% | GEORGEMASON | 11 | University that scored a string of huge upsets in 2006 when it reached the NCAA Final Four: 2 wds. |
| 22% | BONOBO | 6 | One of two species in the genus Pan, the other being the chimpanzee |
| 22% | GTC | 3 | The Roque de los Muchachos Observatory in the Canaries has this largest of its kind observing behemoth (abbr.) |
| 22% | SUMATRANRHINO | 13 | Hunted for its horn, there are barely 200 of these mammals left in Malaysia and Indonesia: 2 wds. |