| 100% | NOROVIRUS | 9 | Infectious agent which causes gastroenteritis |
| 67% | VIRUS | 5 | Small infectious agent which can cause diseases |
| 39% | GERM | 4 | Infectious agent |
| 39% | VIRUSES | 7 | Infectious agents |
| 38% | ECOLI | 5 | Bacteria that may cause gastroenteritis |
| 35% | ECOLI | 5 | Gastroenteritis cause |
| 35% | LSD | 3 | Powerful drug which causes hallucinations |
| 34% | ECOLI | 5 | Gastroenteritis cause, maybe |
| 31% | OIL | 3 | Lubricating agent which is also known as black gold |
| 30% | ARTHRITIS | 9 | Disease such as gout which causes inflammation of the joints |
| 30% | POX | 3 | Infectious disease that causes a rash |
| 29% | BSE | 3 | Scourge of cattle farmers, in brief, which causes loss of muscle control |
| 27% | CHIGGER | 7 | Mite, the larvae of which bite and cause weals |
| 26% | SMART | 5 | "Get ___" (2008 film in which Anne Hathaway plays Agent 99) |
| 26% | SPY | 3 | 2015 movie in which Melissa McCarthy plays a CIA agent |
| 26% | SPY | 3 | Melissa McCarthy film in which she plays a CIA agent |
| 26% | TOADS | 5 | Cousins to frogs, which are said to cause warts (plural) |
| 26% | LETHE | 5 | River in Hades in Greek mythology which caused forgetfulness in those who drank its waters |
| 26% | SALMONELLA | 10 | Genus of bacteria occurring mainly in the gut, many species of which cause food poisoning |
| 25% | HANNIBAL | 8 | NBC drama in which Laurence Fishburne played FBI Special Agent Jack Crawford |
| 25% | VIRUS | 5 | Disease-causing agent |
| 25% | OXIDANT | 7 | Rust-causing agent |
| 25% | OXIDANTS | 8 | Rust-causing agents |
| 24% | TWINPEAKS | 9 | Series on which Kyle MacLachlan plays FBI Special Agent Dale Cooper: 2 wds. |
| 23% | DRINKME | 7 | Words on a bottle that Alice finds in 17a which causes her to shrink in size: 2 wds. |
| 23% | CRIMINALMINDS | 13 | Long-running CBS drama in which 39-Across played an FBI agent: 2 wds. |
| 23% | LOSANGELES | 10 | "NCIS: ___," action series in which Chris O'Donnell plays Agent G. Callen: 2 wds. |
| 23% | NOWYOUSEEME | 11 | 2013 heist film in which Mark Ruffalo plays FBI agent Dylan Rhodes: 4 wds. |
| 23% | THEXFILES | 9 | TV series in which Gillian Anderson played FBI agent Dana Scully: 2 wds., hyph. |
| 22% | LSD | 3 | Infectious cattle complaint caused by the Neethling virus and characterized by nodules on the skin |