| 100% | HARP | 4 | Instrument played by Sheila Bromberg on the Beatles' "She's Leaving Home" |
| 44% | HARP | 4 | First instrument heard in the Beatles' "She's Leaving Home" |
| 43% | HOME | 4 | "She's Leaving ___," song by Lennon-McCartney in which the band members did not play any instruments |
| 40% | UKULELE | 7 | Instrument played by Israel Kamakawiwo'ole on his "Over the Rainbow" medley |
| 38% | DRUMS | 5 | Instrument played by Animal on "The Muppet Show" |
| 38% | DRUM | 4 | Instrument played by Animal on “The Muppet Show” |
| 37% | SAX | 3 | Instrument played by Bleeding Gums Murphy on "The Simpsons" |
| 35% | SOMETHING | 9 | Beatles song by George Harrison on 48-Across with the lyrics "I don't want to leave her now / You know I believe and how" |
| 35% | HARP | 4 | Stringed instrument played by Amy Farrah Fowler on "The Big Bang Theory" |
| 35% | SHELOVESYOU | 11 | Song played by the Beatles on their first two appearances on "The 23-Across Show" (3 wds.) |
| 35% | ALLMYLOVING | 11 | First song played by the Beatles on their first appearance on "The 23-Across Show" (3 wds.) |
| 35% | PIANO | 5 | Instrument played by tickling the ivories |
| 34% | PIANO | 5 | Instrument played by the Queen of Soul |
| 34% | SHES | 4 | The Beatles' "___ Leaving Home" |
| 34% | SHES | 4 | The Beatles' "__ Leaving Home" |
| 33% | MARGARET | 8 | She's played by Helena Bonham Carter in The Crown |
| 33% | SITAR | 5 | Instrument on the Beatles' "Norwegian Wood" |
| 33% | EAR | 3 | Play by ___ (handle on the spot) |
| 33% | SAX | 3 | Instrument famously played by Bill Clinton on "The Arsenio Hall Show" |
| 32% | SITAR | 5 | Instrument played by Brian Jones on “Paint It Black” |
| 32% | SITAR | 5 | Instrument on the Beatles' "Within You Without You" |
| 32% | ARCHIEANDREWS | 13 | Comics character played by KJ Apa on The CW's "Riverdale" (2 wds.) |
| 32% | BETTYCOOPER | 11 | Comics character played by Lili Reinhart on The CW's "Riverdale" (2 wds.) |
| 32% | VERONICALODGE | 13 | Comics character played by Camila Mendes on The CW's "Riverdale" (2 wds.) |
| 31% | SITARS | 6 | Instruments used by the Beatles |
| 31% | ETHEL | 5 | Muggs who was played by Shannon Purser on The CW's "Riverdale" |
| 31% | BELLS | 5 | "Jingle ___," iconic Christmas carol that was the first song played on musical instruments in space by Gemini 6 astronauts in 1965 |
| 31% | DIANA | 5 | Princess played by Emma Corrin on The Crown |
| 31% | PEDALSTEELGUITAR | 16 | Stringed instrument played by Jerry Garcia in the intro to CSNY's "Teach Your Children" |
| 31% | OBOE | 4 | Woodwind played by Hailey on "Mozart in the Jungle" |