| 100% | ADLER | 5 | Irene who was played by Rachel McAdams in 2009’s “Sherlock Holmes” |
| 53% | MCADAMS | 7 | Rachel —, actress who played Irene Adler in 2009 action film Sherlock Holmes |
| 47% | ENOLA | 5 | Holmes who was played by Millie Bobby Brown in 2020 and 2022 |
| 46% | MARY | 4 | ___ Morstan, Watson's wife in the Sherlock Holmes stories who was played by Amanda Abbington on screen |
| 42% | NITTI | 5 | Frank who was played by Stallone in "Capone" |
| 41% | ETTA | 4 | Singer James who was played by Beyoncé in a movie |
| 41% | EVA | 3 | Perón who was played by Madonna in a movie musical |
| 41% | EVA | 3 | Perón who was played by Madonna in a 1996 movie |
| 41% | ETTA | 4 | Singer ___ James who was played by Beyoncé in "Cadillac Records" |
| 41% | EVA | 3 | Perón who was played by Madonna in a 1996 movie musical |
| 41% | ETTA | 4 | Jazz singer James who was played by Beyoncé in "Cadillac Records" |
| 41% | ETTA | 4 | James who was played by Beyoncé in the biopic "Cadillac Records" |
| 40% | ADLER | 5 | Irene who was the only woman to outwit Sherlock Holmes |
| 40% | IRENE | 5 | Rachel McAdams's role in "Sherlock Holmes" |
| 39% | IRIS | 4 | Novelist Murdoch who was played by Kate Winslet and Judi Dench in a 2001 biopic |
| 39% | EVA | 3 | Political leader Perón who was played in a movie by Madonna |
| 39% | OYL | 3 | Olive who was played in "Popeye" by the late Shelley Duvall |
| 38% | TEENA | 5 | Brandon who was played by Hilary Swank in "Boys Don't Cry" |
| 38% | ORSON | 5 | Director Welles who was played by Tom Burke in "Mank" |
| 38% | IRENE | 5 | Rachel McAdams's role in "Sherlock Holmes: A Game of Shadows" |
| 38% | EARP | 4 | Old West lawman Wyatt who was played in a movie by Kevin Costner |
| 38% | JIM | 3 | Astronaut Lovell who was played by Tom Hanks in "Apollo 13" |
| 37% | ANITA | 5 | Lawyer Hill who was played by Viola Davis in the HBO movie "Confirmation" |
| 37% | WICK | 4 | John who's been played in four movies by Keanu Reeves |
| 37% | ELIOT | 5 | Prohibition agent Ness who was played by Kevin Costner in "The Untouchables" |
| 36% | ETHEL | 5 | Muggs who was played by Shannon Purser on The CW's "Riverdale" |
| 36% | DOCTORSTRANGE | 13 | Marvel superhero who was played by Benedict Cumberbatch in the titular 2016 film: 2 wds. |
| 36% | CULLEN | 6 | Fictional vampire Edward who is played by Robert Pattinson in the "Twilight" films |
| 36% | BRADBELLICK | 11 | Character played by Wade Williams who is introduced as the captain of Fox River's correctional officers in "Prison Break": 2 wds. |
| 36% | IRENE | 5 | ___ Adler, iconic character from the Sherlock Holmes stories who was played by Lara Pulver on screen |