| 100% | ATL | 3 | It separates Amer. from Eur. |
| 56% | WHEY | 4 | It separates from curd |
| 55% | PER | 3 | It separates ''pay'' from ''view'' |
| 55% | NILE | 4 | It separates Cairo from Giza |
| 55% | IDAHO | 5 | It separates Oregon from Wyoming |
| 54% | ALCOHOL | 7 | It separates wine from Welch's |
| 54% | KOSOVO | 6 | It separated from Serbia in 2008 |
| 53% | CURB | 4 | It separates the street from the sidewalk |
| 53% | EASTRIVER | 9 | It separates Manhattan Island from Long Island |
| 52% | STRAITOFMESSINA | 15 | It separates Sicily from the rest of Italy |
| 52% | ALASKAPENINSULA | 15 | It separates the Bering Sea from the Pacific |
| 52% | WABASHRIVER | 11 | It separates Terre Haute from West Terre Haute |
| 50% | WHEAT | 5 | It's separated from the chaff |
| 49% | UNHITCHED | 9 | Separated, as a horse from its carriage |
| 49% | CHAFF | 5 | Wheat is separated from it |
| 47% | INC | 3 | Corporate entity separate from its owners (abbr) |
| 46% | PEI | 3 | It's separated from N.B. by the Northumberland Strait |
| 46% | ASIA | 4 | It's separated from North America by the Bering Strait |
| 46% | CLINGY | 6 | Finding it hard to separate from someone else |
| 45% | IRELAND | 7 | It's separated from Iceland by a sea (and a "c"!) |
| 42% | SCO | 3 | Proposed top level domain for Scotland, should it ever separate from the UK |
| 40% | THRESHER | 8 | A machine that separates grains from its plant |
| 40% | EXCLAVE | 7 | Part of a country that's separated from its mainland and surrounded by different country |
| 40% | ACT | 3 | It separates two breaks |
| 40% | NEE | 3 | It separates two names |
| 40% | ANY | 3 | It separates by means |
| 40% | VERSUS | 6 | It separates two boxers |
| 39% | ISNT | 4 | It separates money and everything |
| 39% | ARMREST | 7 | It separates two airplane seats |
| 38% | DOT | 3 | It separates the dollars and cents |