| 100% | RADIO | 5 | It was used to play music for the first time in 1906 |
| 45% | LODESTONE | 9 | It was used to make the first compass |
| 45% | BAKER | 5 | "I used to be a ___ until I found out I was in it for the dough!" |
| 44% | SAUDIS | 6 | Women who were legally permitted to drive for the first time in 2018 |
| 43% | CLASS | 5 | Remember the first time you were chosen as the ___ monitor (student leader) and got to be in charge for the day? Best. Day. Ever! |
| 40% | ICE | 3 | ___ hockey, Winter Olympic sport in which two teams use sticks to shoot a rubber puck and was first played in the 19th century |
| 40% | USPOSTAGE | 9 | It fell in 2016 for the first time since 1919 |
| 40% | ASIA | 4 | Where the Olympics were held for the first time in 1964 |
| 40% | TECATE | 6 | Mexican beer named for the city it was first produced in |
| 39% | DRWHO | 5 | BBC classic whose title role will be played by a woman for the first time in 2017 |
| 39% | ALYN | 4 | Kirk ___, the first actor to play Superman in live-action for the 1948 movie |
| 39% | TRL | 3 | The last music video it played was for a Britney Spears song |
| 38% | GRAYHOLE | 8 | Outer space phenomenon photographed for the first time in 2019 |
| 38% | SAUDI | 5 | ___ Arabia (nation where women voted for the first time in 2015) |
| 38% | WOMENSWORLDCUP | 14 | FIFA event held for the first time in 1991 (3 wds.) |
| 38% | OLDSTYLE | 8 | In the way it used to be |
| 38% | PREMIERES | 9 | Plays for the first time |
| 38% | CHRISTEN | 8 | Use for the first time |
| 38% | GINSU | 5 | First brand to use the phrase “But wait, there’s more!” in its infomercials |
| 38% | ACHES | 5 | Some things to complain about after you've just played flag football for the first time in nine years |
| 37% | CLARINET | 8 | Mozart was the first major composer to write specifically for it |
| 37% | BABYLON | 7 | "___ 5," one of the first television series to use CGI as the primary method for its visual effects |
| 37% | ILSA | 4 | Character who says “Kiss me as if it were the last time” to Rick, in a 1942 film |
| 37% | PEN | 3 | Remember the first time you were allowed to use a ___ (ink-filled writing tool) instead of a pencil at school? Best. Day. Ever! |
| 37% | HARRYSTYLES | 11 | Singer whose "As It Was" won the MTV Video Music Award for Best Pop Video in 2022: 2 wds. |
| 37% | DOT | 3 | In music, the symbol placed after a note to increase its time value by a half |
| 37% | JAMESBOND | 9 | British spy played by 33-Across for the first time in 48-Across (2 wds.) |
| 37% | MARINEONE | 9 | Presidential carrier that flew with an all-women crew for the first time in 2009 |
| 36% | SNL | 3 | Buck Henry was the first to host it five times, briefly |
| 36% | UKE | 3 | Instrument that might be used to play "Hi'ilawe," for short |