| 100% | LIFE | 4 | Its first documented appearance was 3.5 billion years ago |
| 34% | EON | 3 | The Hadean was the first one, ending about 4 billion years ago |
| 30% | CANDY | 5 | With 5-Down, 9+ billion kernels of it are produced annually (happy Halloween!) |
| 30% | NYS | 3 | George Clinton was its first gov. (for 21 years) |
| 30% | TITANIC | 7 | Film that was rereleased in 3-D nearly fifteen years after its initial première |
| 30% | MARCH | 5 | Month that was the first of the new year in early 3-Down calendars |
| 30% | MAGNACARTA | 10 | Document whose original version was annulled by the Pope the same year it was adopted, in 1215 |
| 30% | DESPACITO | 9 | 2017 chart-topping hit whose YouTube video was the first to reach 3 billion views |
| 29% | ERA | 3 | Legislation ratified by Va. in 2020, nearly a hundred years after it was first introduced |
| 29% | AMENDMENTI | 10 | Its first word is "Congress" |
| 29% | APRIL | 5 | Its first is for fools |
| 28% | RAMADA | 6 | Its first hotel was in Flagstaff |
| 28% | FILA | 4 | Its first endorser was Bjorn Borg |
| 28% | IMAC | 4 | Its first version was egg-shaped |
| 28% | IKEA | 4 | Its first store was in Älmhult |
| 28% | ISLAM | 5 | Its first pillar is the shahada |
| 28% | BANG | 4 | The Big one happened 13.8 billion years ago |
| 28% | OED | 3 | Some 3.5 million quotations were gathered for it, for short |
| 28% | PANAM | 5 | Its first route was Key West-Havana |
| 28% | TOYOTA | 6 | Its first car was the Model AA |
| 28% | OHIO | 4 | Its first capital was Chillicothe, 1803-10 |
| 28% | IKEA | 4 | Its first store was in Älmhult, Smaland |
| 28% | AIRMAIL | 7 | Its first stamps were issued in 1918 |
| 28% | ODE | 3 | Its first part is called a strophe |
| 28% | TODOLIST | 8 | Its first item is sometimes jokingly meta |
| 28% | AIDA | 4 | Its first scene is set near Memphis |
| 28% | NRA | 3 | Its first pres. was Gen. Burnside |
| 28% | AFL | 3 | Its first pres. was Samuel Gompers |
| 28% | LEVERET | 7 | Hare in its first year |
| 28% | EBAY | 4 | Its first sale was a broken laser pointer |