| 100% | GARN | 4 | Jake who was in both the Senate and space |
| 57% | FEY | 3 | Tina who was in both the 2004 and 2024 films of "Mean Girls" |
| 47% | DOMINICTHIEM | 12 | Austrian tennis pro who was runner-up to Rafael Nadal at the French Open in both 2018 and 2019 (2 wds.) |
| 47% | JEREMYPENA | 10 | 33-Across shortstop who was named MVP of both the American League Championship Series and the World Series in 2022 (2 wds.) |
| 47% | YURI | 4 | Cosmonaut Gagarin who was the first person in space |
| 47% | ALAN | 4 | Astronaut Shepard who was the first American in space |
| 47% | MAE | 3 | Jemison who was the first Black woman in space |
| 47% | RESNIK | 6 | Judith who was the second American woman in space |
| 47% | JEMISON | 7 | Mae who was the first Black woman in space |
| 47% | YURI | 4 | Gagarin who was the first human in outer space |
| 47% | OCHOA | 5 | Astronaut Ellen who was the first Latina in space |
| 47% | ELLEN | 5 | Astronaut Ochoa who was the first Latina in space |
| 47% | NICKJONAS | 9 | "Jealous" pop singer who both hosted and was the musical act in a 2021 "SNL" episode: 2 wds. |
| 47% | BADBUNNY | 8 | "Moscow Mule" rapper who both hosted and was the musical act in a 2023 "SNL" episode: 2 wds. |
| 47% | MCADAMS | 7 | Rachel who was in Mean Girls and The Notebook |
| 46% | LINDSAY | 7 | Lohan who was in Mean Girls and The Parent Trap |
| 46% | MEGANTHEE | 9 | With 46-Across, "Savage" rapper who both hosted and was the musical act in a 2022 "SNL" episode: 2 wds. |
| 46% | SALLY | 5 | ___ Ride who was the first American woman in space |
| 45% | CANDACEPARKER | 13 | Chicago Sky star who was named both WNBA Rookie of the Year and WNBA MVP in 2008: 2 wds. |
| 45% | LAIKA | 5 | Dog who was the first animal in space |
| 45% | SHEPARD | 7 | Alan who was the first American in space |
| 44% | EDITOR | 6 | Person who is in charge of and determines the final content of a text |
| 44% | MEL | 3 | Blanc who was the voice of both Tweety and Sylvester |
| 44% | YURI | 4 | Cosmonaut Gagarin who was the first human in outer space |
| 44% | ALEKSEI | 7 | Leonov who was the first man to walk in space |
| 44% | RIDE | 4 | Astronaut Sally who was the first American woman in space |
| 44% | MAE | 3 | Astronaut Jemison who was the first Black woman in space |
| 44% | OCHOA | 5 | Astronaut Ellen who was the first Hispanic woman in space |
| 44% | MAE | 3 | Astronaut Jemison who was the first African-American woman in space |
| 44% | NASH | 4 | Steve who was the NBA's MVP in 2005 and 2006 |