| 100% | RENO | 4 | Janet who was the first woman to serve as U.S. attorney general |
| 65% | JANETRENO | 9 | First woman to serve as attorney general of the US: 2 wds. |
| 65% | JANET | 5 | With 28-Down, first woman to serve as U.S. attorney general |
| 63% | RENO | 4 | Janet, first woman to serve as the Attorney General of the United States |
| 61% | SAHLE | 5 | ___-Work Zewde, Ethiopian politician who is the first woman to serve as the President of Ethiopia |
| 61% | MIA | 3 | ___ Mottley, Barbadian politician who is the first woman to serve as the Prime Minister of Barbados |
| 61% | DEVI | 4 | Bidya ___ Bhandari, Nepalese politician who is the first woman to serve as the President of Nepal |
| 60% | RENO | 4 | Janet who was the U.S.’s first female Attorney General |
| 59% | RENO | 4 | Janet who was the first female US attorney general |
| 57% | LORETTA | 7 | ___ Lynch, first African American woman to serve as U.S. attorney general |
| 53% | RENO | 4 | First woman to serve as attorney general |
| 53% | RENO | 4 | Janet who was the first female attorney general |
| 51% | RENO | 4 | Janet who was the US Attorney General, 1993-2001 |
| 51% | BLACKWELL | 9 | Elizabeth ___, British physician who was the first woman to earn a medical degree in the US |
| 51% | RENO | 4 | Janet who was the Attorney General from 1993 to 2001 |
| 48% | ERIC | 4 | Holder who was the first African-American US Attorney General |
| 47% | RENO | 4 | Janet who served as US attorney general, 1993-2001 |
| 47% | LEE | 3 | Rebecca ___ Crumpler, physician who was the first African-American woman in the US to earn a medical degree |
| 46% | COURIC | 6 | Journalist who was the first woman to guest-host "Jeopardy!" |
| 46% | REBA | 4 | Singer McEntire who was the first woman to play Colonel Sanders |
| 46% | DOMEE | 5 | Shi who was the first woman to have the sole director’s credit on a Pixar feature, for “Turning Red” |
| 46% | KAMALAHARRIS | 12 | Former California senator who is the first woman and first person of color to be inaugurated as vice president of the United States (2 wds.) |
| 46% | JEN | 3 | Cartoonist Sorensen who was the first woman to win the Herblock Prize |
| 46% | ZAHA | 4 | Hadid who was the first woman to win the Pritzker Architecture Prize |
| 46% | KATIECOURIC | 11 | Journalist who was the first woman to guest-host "Jeopardy!" (2 wds.) |
| 45% | EDITH | 5 | Wharton who was the first woman to win the Pulitzer Prize for Literature |
| 45% | ROSA | 4 | Parks who was the first woman to lie in honor in the Capitol |
| 45% | EDITH | 5 | Wharton who was the first woman to win a Pulitzer Prize for fiction |
| 45% | JACINDA | 7 | ___ Ardern, New Zealand politician who is the youngest woman to serve as the Prime Minister of New Zealand |
| 45% | MARYAM | 6 | ___ Mirzakhani, an Iranian mathematician who was the first woman to receive the Fields Medal |